{"created":"2024-12-09T09:36:32.120587+00:00","id":2002136,"links":{},"metadata":{"_buckets":{"deposit":"d99fbe02-5661-4099-ae30-d6f4ea72632d"},"_deposit":{"created_by":41,"id":"2002136","owners":[41],"pid":{"revision_id":0,"type":"depid","value":"2002136"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:02002136","sets":["14:2667:1728522335637:1728528767433"]},"author_link":[],"item_1693378644159":{"attribute_name":"研究分担者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"12301","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"群馬大学","affiliationNameLang":"ja"},{"affiliationName":"Gunma University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"高橋, 昭久","creatorNameLang":"ja"},{"creatorName":"Takahashi, Akihisa","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"60275336","nameIdentifierScheme":"e-Rad"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"24601","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"奈良県立医科大学","affiliationNameLang":"ja"},{"affiliationName":"Nara Medical University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"森, 英一朗","creatorNameLang":"ja"},{"creatorName":"Mori, Ei-ichiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"70803659","nameIdentifierScheme":"e-Rad"}]}]},"item_1693381679919":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"=資源タイプ識別子":"http://purl.org/coar/resource_type/c_93fc","resourcetype":"report","resourceuri":"http://purl.org/coar/resource_type/c_93fc"}]},"item_30001_bibliographic_information17":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicNumberOfPages":"5","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2023)","bibliographic_titleLang":"ja"}]}]},"item_30001_creator2":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"34419","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"太田, 一郎","creatorNameLang":"ja"},{"creatorName":"Ota, Ichiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"00326323","nameIdentifierScheme":"e-Rad_Researcher"}]}]},"item_30001_description8":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"がん微小環境においてがん細胞がEMT（Epithelial-Mesenchymal Transition）を誘導するとともにがん幹細胞の活性化を促進し、どのようにして腫瘍免疫抑制・回避能を獲得するのかを検討した。EMT のがん微小環境における免疫逃避能獲得の関与が示唆され、EMT 亢進と PD-L1 発現は一方向性ではなく、複雑な双方向性であることが示唆された。またPD-L1/PD-L2 をノックダウンすることで EMT を抑制することが示唆された。がん細胞のEMTの発現誘導がPD-L1/PD-L2を介した腫瘍免疫抑制・回避能と密接に相互関係を保ちながら制御されていることが示唆された。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"We investigated how cancer cells induce Epithelial-Mesenchymal Transition (EMT) and promote cancer stem cell activation in the cancer microenvironment and how they acquire tumor immunosuppression and evasion ability. The involvement of EMT in the acquisition of immune escape capacity in the cancer microenvironment was suggested. The results indicated that EMT enhancement and PD-L1 expression are not unidirectional, but rather complex and bidirectional. Knockdown of PD-L1/PD-L2 was found to suppress EMT. These data suggested that the induction of EMT expression in cancer cells is regulated in close interrelation with tumor immunosuppression and evasion ability via PD-L1/PD-L2.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"研究分野：耳鼻咽喉科","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_30001_file22":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"20K09718seika.pdf","filesize":[{"value":"159.1 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://kindai.repo.nii.ac.jp/record/2002136/files/20K09718seika.pdf"},"version_id":"17c33aac-207e-4b9a-96e1-031471f0bc3e"}]},"item_30001_funding_reference15":{"attribute_name":"助成情報","attribute_value_mlt":[{"subitem_award_numbers":{"subitem_award_number":"20K09718","subitem_award_uri":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K09718/"},"subitem_award_titles":[{"subitem_award_title":"がん微小環境における頭頸部がん幹細胞のEMTを介した腫瘍免疫抑制と回避の解明","subitem_award_title_language":"ja"},{"subitem_award_title":"EMT-mediated tumor immunosuppression and evasion of head and neck cancer stem cells in the cancer microenvironment","subitem_award_title_language":"en"}],"subitem_funder_names":[{"subitem_funder_name":"独立行政法人日本学術振興会","subitem_funder_name_language":"ja"},{"subitem_funder_name":"Japan Society for the Promotion of Science","subitem_funder_name_language":"en"}]}]},"item_30001_language10":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_30001_subject7":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"がん微小環境　","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"がんの浸潤・転移","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"EMT","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_30001_title0":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"がん微小環境における頭頸部がん幹細胞のEMTを介した腫瘍免疫抑制と回避の解明","subitem_title_language":"ja"},{"subitem_title":"EMT-mediated tumor immunosuppression and evasion of head and neck cancer stem cells in the cancer microenvironment","subitem_title_language":"en"}]},"item_30001_version_type12":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_title":"がん微小環境における頭頸部がん幹細胞のEMTを介した腫瘍免疫抑制と回避の解明","item_type_id":"40001","owner":"41","path":["1728528767433"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-11-08"},"publish_date":"2024-11-08","publish_status":"0","recid":"2002136","relation_version_is_last":true,"title":["がん微小環境における頭頸部がん幹細胞のEMTを介した腫瘍免疫抑制と回避の解明"],"weko_creator_id":"41","weko_shared_id":-1},"updated":"2024-12-13T08:14:47.096780+00:00"}