{"created":"2024-12-09T07:54:45.718616+00:00","id":2002119,"links":{},"metadata":{"_buckets":{"deposit":"93f136d8-0669-4047-b1ed-d7b175bf3671"},"_deposit":{"created_by":41,"id":"2002119","owners":[41],"pid":{"revision_id":0,"type":"depid","value":"2002119"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:02002119","sets":["14:2667:1728522335637:1728528711661"]},"author_link":[],"control_number":"2002119","item_1693381679919":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"=資源タイプ識別子":"http://purl.org/coar/resource_type/c_93fc","resourcetype":"report","resourceuri":"http://purl.org/coar/resource_type/c_93fc"}]},"item_30001_bibliographic_information17":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicNumberOfPages":"11","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2023)","bibliographic_titleLang":"ja"}]}]},"item_30001_creator2":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"34419","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"宮下, 尚之","creatorNameLang":"ja"},{"creatorName":"Miyashita, Naoyuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"20452162","nameIdentifierScheme":"e-Rad_Researcher"}]}]},"item_30001_description8":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"アミロイドβペプチド（Aβ）は、β切断酵素によりアミロイド前駆体タンパク質（APP）の細胞外部位が切断され、続いてγ切断酵素により膜貫通部位が切断されることで産生される。Aβの凝集により老人斑が生成される。一方、通常のAPPはα切断酵素によりAPPの細胞外領域が切断される。現在、切断酵素、APPの全長構造はわかっていない。またAPPの切断酵素による切断に至るまでのメカニズムもわかっていない。そこで本研究では①αとβ切断酵素の全長構造とAPPの必要な部位の構造をREMDやAlpha Fold2などで予測し、それらのダイナミクスから、②APPの切断酵素へのアプローチの仕方について調べた。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"Amyloid beta peptide (Aβ) is produced by the cleavage of the extracellular region of amyloid precursor protein (APP) by β-secretase, followed by the cleavage of the transmembrane region by γ-secretase. The aggregation of Aβ leads to the formation of senile plaques. On the other hand, normal APP is cleaved in its extracellular region by α-secretase. Currently, the full-length structures of the secretases and APP are not known. Additionally, the mechanism leading to the cleavage of APP by these secretases is also unclear. In this study, we aimed to (1) predict the full-length structures of α- and β-secretases and the necessary regions of APP using REMD and AlphaFold2, and (2) investigate the approach of APP to the secretases based on their dynamics.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"研究分野：生体分子シミュレーション","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_30001_file22":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-12-16"}],"filename":"21K12115seika.pdf","filesize":[{"value":"286 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://kindai.repo.nii.ac.jp/record/2002119/files/21K12115seika.pdf"},"version_id":"d22a8456-3021-4bbd-97c2-a6b04261aaeb"}]},"item_30001_funding_reference15":{"attribute_name":"助成情報","attribute_value_mlt":[{"subitem_award_numbers":{"subitem_award_number":"21K12115","subitem_award_uri":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K12115/"},"subitem_award_titles":[{"subitem_award_title":"分子シミュレーションを用いたアルツハイマー病におけるAβ産生の起点機構の詳細解明","subitem_award_title_language":"ja"},{"subitem_award_title":"Molecular Dynamics Study on the Mechanism of Amyloid Beta Production in the Early Stages of Alzheimer's Disease.","subitem_award_title_language":"en"}],"subitem_funder_names":[{"subitem_funder_name":"独立行政法人日本学術振興会","subitem_funder_name_language":"ja"},{"subitem_funder_name":"Japan Society for the Promotion of Science","subitem_funder_name_language":"en"}]}]},"item_30001_language10":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_30001_subject7":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"構造予測","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"相互作用計算","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"分子動力学シミュレーション","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"アルツハイマー病","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"アミロイド前駆体タンパク質","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"切断酵素","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_30001_title0":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"分子シミュレーションを用いたアルツハイマー病におけるAβ産生の起点機構の詳細解明","subitem_title_language":"ja"},{"subitem_title":"Molecular Dynamics Study on the Mechanism of Amyloid Beta Production in the Early Stages of Alzheimer's Disease.","subitem_title_language":"en"}]},"item_30001_version_type12":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_title":"分子シミュレーションを用いたアルツハイマー病におけるAβ産生の起点機構の詳細解明","item_type_id":"40001","owner":"41","path":["1728528711661"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-11-08"},"publish_date":"2024-11-08","publish_status":"0","recid":"2002119","relation_version_is_last":true,"title":["分子シミュレーションを用いたアルツハイマー病におけるAβ産生の起点機構の詳細解明"],"weko_creator_id":"41","weko_shared_id":-1},"updated":"2024-12-16T08:48:25.563160+00:00"}