{"created":"2024-12-09T00:46:36.983093+00:00","id":2002103,"links":{},"metadata":{"_buckets":{"deposit":"63ebfb60-3da8-48b4-9683-e7efe51d1886"},"_deposit":{"created_by":42,"id":"2002103","owners":[42],"pid":{"revision_id":0,"type":"depid","value":"2002103"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:02002103","sets":["14:2667:1728522335637:1728528848310"]},"author_link":[],"control_number":"2002103","item_1693378644159":{"attribute_name":"研究分担者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"12102","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"筑波大学","affiliationNameLang":"ja"},{"affiliationName":"University of Tsukuba","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"丹羽, 隆介","creatorNameLang":"ja"},{"creatorName":"Niwa, Ryusuke","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"60507945","nameIdentifierScheme":"e-Rad"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"34428","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"摂南大学","affiliationNameLang":"ja"},{"affiliationName":"setsunan University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"加藤, 直樹","creatorNameLang":"ja"},{"creatorName":"Kato, Naoki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"90442946","nameIdentifierScheme":"e-Rad"}]}]},"item_1693381679919":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"=資源タイプ識別子":"http://purl.org/coar/resource_type/c_93fc","resourcetype":"report","resourceuri":"http://purl.org/coar/resource_type/c_93fc"}]},"item_30001_bibliographic_information17":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicNumberOfPages":"18","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2023)","bibliographic_titleLang":"ja"}]}]},"item_30001_creator2":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"34419","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"松田,一彦","creatorNameLang":"ja"},{"creatorName":"Matsuda, Kazuhiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"00199796","nameIdentifierScheme":"e-Rad_Researcher"}]}]},"item_30001_description8":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"本研究ではショウジョウバエのnAChRを対象として、Dα2サブユニットがネオニコチノイドとの相互作用に負に働き、その発現を抑制するとショウジョウバエ成虫がネオニコチノイド過敏になることを発見した。次いで、セイヨウミツバチで発現するnAChRのサブユニットと補助因子の共発現を遺伝子発現解析によって明らかにし、補助因子が濃度依存的にnAChRの膜上での機能的発現を調節することを見出した。さらに線虫のnAChRに対する糸状菌産物パラヘルクアミドAの選択的作用の機構を解明し、変態依存的なnAChRの調節の研究に有用なケミカルプローブを糸状菌産物から見出した。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"In the present study, the PI found that the Dα2 subunit negatively interacts with neonicotinoids and that suppressing its expression causes neonicotinoid hypersensitivity in adult Drosophila melanogaster. Next, gene expression analysis revealed co-expression of auxiliary factors with subunits of nAChR expressed in the honeybee, and found that auxiliary factors modulate the functional expression of nAChR on the membrane in a concentration-dependent manner. Furthermore, the mechanism of the selective action of the fungal product paraherquamide A on the C. elegans nAChR was elucidated, and chemical probes useful for studying metamorphosis-dependent regulation of the nAChR were found from the fungal products.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"研究分野：Pesticide Science","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_30001_file22":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"21H04718seika.pdf","filesize":[{"value":"279.3 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://kindai.repo.nii.ac.jp/record/2002103/files/21H04718seika.pdf"},"version_id":"13c96c72-567e-4504-b67a-a5d53f7c6a49"}]},"item_30001_funding_reference15":{"attribute_name":"助成情報","attribute_value_mlt":[{"subitem_award_numbers":{"subitem_award_number":"21H04718","subitem_award_uri":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21H04718/"},"subitem_award_titles":[{"subitem_award_title":"ニコチン性アセチルコリン受容体のダイナミズムの解明に基づく昆虫制御の先端開拓","subitem_award_title_language":"ja"},{"subitem_award_title":"Frontier research of insect control based on the elucidation of nicotinic acetylcholine receptor dynamism","subitem_award_title_language":"en"}],"subitem_funder_names":[{"subitem_funder_name":"独立行政法人日本学術振興会","subitem_funder_name_language":"ja"},{"subitem_funder_name":"Japan Society for the Promotion of Science","subitem_funder_name_language":"en"}]}]},"item_30001_language10":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_30001_subject7":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Insect regulation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Neonicotinoid","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Nicotinic receptor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Electrophysiology","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Receptor expression","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Multivariate analysis","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_30001_title0":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ニコチン性アセチルコリン受容体のダイナミズムの解明に基づく昆虫制御の先端開拓","subitem_title_language":"ja"},{"subitem_title":"Frontier research of insect control based on the elucidation of nicotinic acetylcholine receptor dynamism","subitem_title_language":"en"}]},"item_30001_version_type12":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_title":"ニコチン性アセチルコリン受容体のダイナミズムの解明に基づく昆虫制御の先端開拓","item_type_id":"40001","owner":"42","path":["1728528848310"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-11-08"},"publish_date":"2024-11-08","publish_status":"0","recid":"2002103","relation_version_is_last":true,"title":["ニコチン性アセチルコリン受容体のダイナミズムの解明に基づく昆虫制御の先端開拓"],"weko_creator_id":"42","weko_shared_id":-1},"updated":"2025-01-07T01:16:03.254677+00:00"}