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血管平滑筋収縮の内皮による調節と高血圧自然発症ラットの血管における異常
https://kindai.repo.nii.ac.jp/records/2002063
https://kindai.repo.nii.ac.jp/records/2002063d61d52be-43c6-4886-8631-16aa96874312
| 名前 / ファイル | ライセンス | アクション |
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AN00063584-19931230-0065.pdf (148.0 KB)
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| Item type | ☆紀要論文 / Departmental Bulletin Paper(1) | |||||||||||||||||||||
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| 公開日 | 2024-11-27 | |||||||||||||||||||||
| タイトル | ||||||||||||||||||||||
| タイトル | 血管平滑筋収縮の内皮による調節と高血圧自然発症ラットの血管における異常 | |||||||||||||||||||||
| 言語 | ja | |||||||||||||||||||||
| タイトル | ||||||||||||||||||||||
| タイトル | Modulation of contraction of aortic smooth muscle by endothelium and its decrease in spontaneously hypertensive rats | |||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
| 著者 |
砂野, 哲
× 砂野, 哲
× 金子, 恭子
× 山本, 和夫
× 佐々木, 富美子
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| 言語 | ||||||||||||||||||||||
| 言語 | jpn | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 主題 | Aorta, noradrenaline-contraction, endothelium, SHRSP | |||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||
| 資源タイプ | departmental bulletin paper | |||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||
| 出版タイプ | AM | |||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||||||||||
| 出版者 名前 | ||||||||||||||||||||||
| 出版者 | 近畿大学医学会 | |||||||||||||||||||||
| 言語 | ja | |||||||||||||||||||||
| bibliographic_information |
ja : 近畿大学医学雑誌 en : Medical Journal of Kinki University 巻 18, 号 4補冊, p. 65-67, 発行日 1993-12-30 |
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| 収録物識別子タイプ | PISSN | |||||||||||||||||||||
| 収録物識別子 | 03858367 | |||||||||||||||||||||
| 内容記述 | ||||||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||||||
| 内容記述 | Noradrenaline-induced contraction was potentiated by the removal of endothelium and the potentiation was greater in the aorta of Wistar Kyoto (WKY) rats than in that of stroke-prone spontaneously hypertensive rats (SHRSP). N^G-nitro-L-arginine (L-NNA, 100μM), which inhibits nitric oxide (NO) synthesis, also potentiated the noradrenaline-induced contraction in the endothelium-intact preparation. The effect of L-NNA was greater in the WKY preparation. Acetylcholine-induced relaxation in the endothelium-intact aorta was impaired in the SHRSP preparation. Phenylephrine- and clonidine-induced contractions were augmented by pretreatment with L-NNA or removal of endothelium. These findings indicate that the vascular endothelium modulates the noradrenaline-induced contraction by releasing NO through α_<1-> and α_<2-> adrenergic receptors. The depression of noradrenaline-induced contraction by the endothelium was augmented by the repetition of the initiation of the contraction. The augmentation of the depression was less prominent in the SHRSP aorta. This also suggests that the release of NO through these adrenergic receptors is reduced in the aorta of SHRSP. | |||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
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| 内容記述タイプ | Other | |||||||||||||||||||||
| 内容記述 | 本文データはCiNiiから複製したものである。 | |||||||||||||||||||||
| 言語 | ja | |||||||||||||||||||||
