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SHRとWKYの心筋におけるSOD活性とフリーラジカル障害の比較
https://kindai.repo.nii.ac.jp/records/2002059
https://kindai.repo.nii.ac.jp/records/2002059d5634617-1eab-4c64-bca0-18e99956a7e7
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AN00063584-19931230-0043.pdf (999.7 KB)
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| Item type | ☆紀要論文 / Departmental Bulletin Paper(1) | |||||||||||||||||
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| 公開日 | 2024-11-27 | |||||||||||||||||
| タイトル | ||||||||||||||||||
| タイトル | SHRとWKYの心筋におけるSOD活性とフリーラジカル障害の比較 | |||||||||||||||||
| 言語 | ja | |||||||||||||||||
| タイトル | ||||||||||||||||||
| タイトル | Comparative study on SOD activity and free radical injury of SHR and WKY myocardium | |||||||||||||||||
| 言語 | en | |||||||||||||||||
| 著者 |
伊藤, 浩行
× 伊藤, 浩行
× 鳥井, 幹則
× 鈴木, 庸之
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| 言語 | ||||||||||||||||||
| 言語 | jpn | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | myocardium, superoxide dismutase, nitroblue tetrazolium, free radical, doxorubicin | |||||||||||||||||
| 資源タイプ | ||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||
| 資源タイプ | departmental bulletin paper | |||||||||||||||||
| 出版タイプ | ||||||||||||||||||
| 出版タイプ | AM | |||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||||||
| 出版者 名前 | ||||||||||||||||||
| 出版者 | 近畿大学医学会 | |||||||||||||||||
| 言語 | ja | |||||||||||||||||
| bibliographic_information |
ja : 近畿大学医学雑誌 en : Medical Journal of Kinki University 巻 18, 号 4補冊, p. 43-47, 発行日 1993-12-30 |
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| ISSN | ||||||||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||||||||
| 収録物識別子 | 03858367 | |||||||||||||||||
| 内容記述 | ||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||
| 内容記述 | To elucidate the myocardial vulnerability of the hypertrophied myocardium in the SHR, the superoxide dismutase (SOD) activity was examined using the mitochondrial and cytosol fraction of 4- and 24-week-old SHR and WKY. Furthermore, superoxide anion production was compared histochemically by the Nitroblue tetrazolium (NBT) perfusion method in 16-week-old SHR and WKY after doxorubicin administration. At 4 weeks of age, the Mn-SOD activity in the mitochondrial fraction was higher in the myocardium in the SHR than in the WKY, whereas no difference was found at 24 weeks of age. CuZn-SOD in the cytosol fraction was significantly lower in the myocardium in the SHR than in the WKY both at 4 and 24 weeks of age. On the other hand, holmazan formation which was generated from NBT by the superoxide anion was more intense in the myocardium in the SHR than in the WKY after doxorubicin administration. These findings indicate that the decreased defense system for free radical injury may be an important factor for myocardial vulnerability in the SHR hypertrophied heart. | |||||||||||||||||
| 言語 | en | |||||||||||||||||
| 内容記述 | ||||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||||
| 内容記述 | 本文データはCiNiiから複製したものである。 | |||||||||||||||||
| 言語 | ja | |||||||||||||||||
