| アイテムタイプ |
☆紀要論文 / Departmental Bulletin Paper(1) |
| 公開日 |
2024-11-27 |
| タイトル |
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タイトル |
Influence of L-NNA and GTN on blood pressure and heart rate in conscious SHRSP and WKY |
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言語 |
en |
| 著者 |
Simeonova, Katerina
Lambev, Ivan
Higashino, Hideaki
Suzuki, Aritomo
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| 言語 |
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言語 |
eng |
| キーワード |
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主題 |
SHRSP, glyceryl trinitrate, N^G-nitro-L-arginine, blood pressure, heart rate |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
departmental bulletin paper |
| 出版タイプ |
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出版タイプ |
AM |
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出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 出版者 名前 |
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出版者 |
近畿大学医学会 |
|
言語 |
ja |
| bibliographic_information |
ja : 近畿大学医学雑誌
en : Medical Journal of Kinki University
巻 18,
号 4補冊,
p. 33-37,
発行日 1993-12-30
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| ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
03858367 |
| 内容記述 |
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内容記述タイプ |
Abstract |
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内容記述 |
We performed comparative studies on conscious restrained 6-month-old female SHRSP and WKY, chronically instrumented for blood pressure (BP) measurement. The potent nitric oxide (NO) inhibitor N^G-nitro-L-arginine (L-NNA, 3 and 6 mg/kg i.v.) produced a dose-related increase in BP with concomitant reduction in heart rate (HR). Systolic arterial pressure (SAP) enhanced more markedly in SHRSP, whereas the decreases in HR were more pronounced in WKY (p<0.05). In the presence of L-NNA, the hypotensive and tachycardic responses to glyceryl trinitrate (GTN, i.v. bolus doses of 3, 10 and 30 μg/kg) were more increased, and the rises in HR were significantly higher in the group of WKY compared to SHRSP. Our findings suggest that L-NNA caused more pronounced effects on the NO-involved system in SHRSP than in WKY. The less bradycardic response in SHRSP compared to WKY after treatment with L-NNA may be caused by disorders in the baroreflex system. The NO-synthase inhibitor, L-NNA, potentiated the vasodilator effect of GTN in WKY as well as in SHRSP rats. |
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言語 |
en |
| 内容記述 |
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内容記述タイプ |
Other |
|
内容記述 |
本文データはCiNiiから複製したものである。 |
|
言語 |
ja |
AN00063584-19931230-0033.pdf (171.5 KB)
