WEKO3
アイテム
Influence of endothelin-1 on systolic arterial pressure and heart rate in conscious WKY and SHRSP
https://kindai.repo.nii.ac.jp/records/2002056
https://kindai.repo.nii.ac.jp/records/2002056f2ddc1d0-209b-498a-b4a1-35c8681467f9
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AN00063584-19931230-0027.pdf (183.4 KB)
|
|
| Item type | ☆紀要論文 / Departmental Bulletin Paper(1) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2024-11-27 | |||||||||||||
| タイトル | ||||||||||||||
| タイトル | Influence of endothelin-1 on systolic arterial pressure and heart rate in conscious WKY and SHRSP | |||||||||||||
| 言語 | en | |||||||||||||
| 著者 |
Lambev, Ivan
× Lambev, Ivan
× Simeonova, Katerina
× Higashino, Hideaki
× Suzuki, Aritomo
|
|||||||||||||
| 言語 | ||||||||||||||
| 言語 | eng | |||||||||||||
| キーワード | ||||||||||||||
| 主題 | SHRSP, WKY, endothelin-1, blood pressure, heart rate | |||||||||||||
| 資源タイプ | ||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||
| 資源タイプ | departmental bulletin paper | |||||||||||||
| 出版タイプ | ||||||||||||||
| 出版タイプ | AM | |||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||
| 出版者 名前 | ||||||||||||||
| 出版者 | 近畿大学医学会 | |||||||||||||
| 言語 | ja | |||||||||||||
| bibliographic_information |
ja : 近畿大学医学雑誌 en : Medical Journal of Kinki University 巻 18, 号 4補冊, p. 27-32, 発行日 1993-12-30 |
|||||||||||||
| ISSN | ||||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||||
| 収録物識別子 | 03858367 | |||||||||||||
| 内容記述 | ||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||
| 内容記述 | In conscious 6-month-old female Wistar Kyoto rats (WKY) and stroke-prone spontaneously hypertensive rats (SHRSP) chronically instrumented for blood pressure (BP) measurement, we investigated the effects of endothelin-1 (ET-1) on systolic arterial pressure (SAP) and heart rate (HR). ET-1 injected intravenously at doses of 0.1, 0.3 and 1 nmol/kg evoked a transient dose-dependent fall in SAP with a corresponding increase in HR. The percent changes of SAP and HR were similar in WKY and SHRSP. The initial decrease in SAP was followed by a dose-dependent sustained rise in SAP with a concomitant decrease in HR in WKY as well as in SHRSP. There was no significant difference between the pressor effects in either rat strain, whereas the reduction in HR after administration of a 1 nmol/kg dose was more marked in WKY (p<0.05). Our findings indicated that the initial transient hypotensive and the subsequent long-lasting pressor effect to ET-1 (0.1, 0.3 and 1 nmol/kg, bolus i.v.) caused the nonsignificant difference between conscious WKY and SHRSP. The corresponding bradycardic response to the blood pressure elevation was less in SHRSP than in WKY which may be due to an attenuation of the baroreflex sensitivity in the hypertensive rats. | |||||||||||||
| 言語 | en | |||||||||||||
| 内容記述 | ||||||||||||||
| 内容記述タイプ | Other | |||||||||||||
| 内容記述 | 本文データはCiNiiから複製したものである。 | |||||||||||||
| 言語 | ja | |||||||||||||
