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Flow cytometryによる核DNA量解析およびPCNA labeling indexからみた胃癌遠隔転移様式の検討
https://kindai.repo.nii.ac.jp/records/2002044
https://kindai.repo.nii.ac.jp/records/2002044e7234946-435f-4bfd-b95b-579dbae861cb
| 名前 / ファイル | ライセンス | アクション |
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AN00063584-19931225-0521.pdf (697.3 KB)
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| Item type | ☆紀要論文 / Departmental Bulletin Paper(1) | |||||||||||||
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| 公開日 | 2024-11-22 | |||||||||||||
| タイトル | ||||||||||||||
| タイトル | Flow cytometryによる核DNA量解析およびPCNA labeling indexからみた胃癌遠隔転移様式の検討 | |||||||||||||
| 言語 | ja | |||||||||||||
| タイトル | ||||||||||||||
| タイトル | Distant metastasis of gastric cancer assessed by flow cytometric analysis of DNA content and PCNA labeling index | |||||||||||||
| 言語 | en | |||||||||||||
| 著者 |
今西, 幸雄
× 今西, 幸雄
× 黒岡, 一仁
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| 言語 | ||||||||||||||
| 言語 | jpn | |||||||||||||
| キーワード | ||||||||||||||
| 主題 | DNA ploidy pattern, DNA index, proliferating cell nuclear antigen, distant metastasis, gastric cancer | |||||||||||||
| 資源タイプ | ||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||
| 資源タイプ | departmental bulletin paper | |||||||||||||
| 出版タイプ | ||||||||||||||
| 出版タイプ | AM | |||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||
| 出版者 名前 | ||||||||||||||
| 出版者 | 近畿大学医学会 | |||||||||||||
| 言語 | ja | |||||||||||||
| bibliographic_information |
ja : 近畿大学医学雑誌 en : Medical Journal of Kinki University 巻 18, 号 4, p. 521-532, 発行日 1993-12-25 |
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| ISSN | ||||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||||
| 収録物識別子 | 03858367 | |||||||||||||
| 内容記述 | ||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||
| 内容記述 | In 216 patients who had undergone surgical treatment of gastric cancer, we investigated whether histopathological factors, DNA ploidy pattern and DNA index (DI) by flow cytometry (FCM) and the labeling index (LI) of proliferating cell nuclear antigen (PCNA) by immunohistochemical staining can be a risk factor of distant metastasis of gastric cancer. In the histopathological factors, the cell-differentiation and venous invasion were important risk factors of distant metastasis of gastric cancer. Studies of DNA ploidy pattern suggested a relationship between DNA aneuploidy and liver metastasis. Furthermore, studies of DI and PCNA LI revealed the absence of recurrence when DI=1.0 and PCNA LI≦40%, but peritoneal dissemination was observed when DI=1.0 and PCNA LI≧50%, while liver metastasis was observed frequently when DI=1.0 and PCNA≧60%. In the case of 1.1≦DI≦1.6 and PCNA LI≦40%, recurrence was not observed, but a possibility of peritoneal dissemination or liver metastasis was very high when PCNA LI≧60%. In addition, when DI≧1.7, the possibility of liver metastasis was extremely high regardless of the presence or absence of cell-differentiation and venous invasion. Thus, the observation of the cell-differentiation and venous invasion in paraffin-embedded tissue of gastric cancer, determination of DNA ploidy pattern and DI from FCM as well as measurement of PCNA LI using immunohistochemical staining were suggested to be very useful for evaluating distant metastasis and malignant potential. | |||||||||||||
| 言語 | en | |||||||||||||
| 内容記述 | ||||||||||||||
| 内容記述タイプ | Other | |||||||||||||
| 内容記述 | 本文データはCiNiiから複製したものである。 | |||||||||||||
| 言語 | ja | |||||||||||||
