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アトピー性皮膚炎患者皮膚表皮の最終分化産物の異常について
https://kindai.repo.nii.ac.jp/records/2002043
https://kindai.repo.nii.ac.jp/records/2002043205dae56-33c7-48ca-9330-c52c40bd88e3
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AN00063584-19931225-0511.pdf (1.0 MB)
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| Item type | ☆紀要論文 / Departmental Bulletin Paper(1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2024-11-22 | |||||||||
| タイトル | ||||||||||
| タイトル | アトピー性皮膚炎患者皮膚表皮の最終分化産物の異常について | |||||||||
| 言語 | ja | |||||||||
| タイトル | ||||||||||
| タイトル | Abnormalities in epidermal terminal differentiation products in skin from patients with atopic dermatitis | |||||||||
| 言語 | en | |||||||||
| 著者 |
瀬口, 得二
× 瀬口, 得二
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| 言語 | ||||||||||
| 言語 | jpn | |||||||||
| キーワード | ||||||||||
| 主題 | atopic dermatitis, filaggrin, cystatin A, involucrin, immunohistochemistry, quantitative analysis | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | departmental bulletin paper | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | AM | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||
| 出版者 名前 | ||||||||||
| 出版者 | 近畿大学医学会 | |||||||||
| 言語 | ja | |||||||||
| bibliographic_information |
ja : 近畿大学医学雑誌 en : Medical Journal of Kinki University 巻 18, 号 4, p. 511-519, 発行日 1993-12-25 |
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| ISSN | ||||||||||
| 収録物識別子タイプ | PISSN | |||||||||
| 収録物識別子 | 03858367 | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | Filaggrin, cystatin A and involucrin are the principal products of epidermal terminal differentiation. They are required for normal formation of the stratum corneum. However the surface of the skin of patients with atopic dermatitis is always dry and easily becomes itchy, indicating abnormal stratum corneum formation. This study investigated the cause of the dryness of the skin surface in patients with atopic dermatitis. Paraffin-embedded sections of specimens of skin obtained from 27 patients with atopic dermatitis were labelled with anti-human filaggrin, anti-human cystatin A and anti-human involucrin antibodies, and the amounts of reaction products were determined using a chromato-scanning meter. The amount of filaggrin was 4.89±0.36 g (n=12) in control skin (NS). In contrast, there were respectively 2.40±0.37μg (n=12) and 2.91±0.40μg (n=4) of filaggrin in lesional skin (AD-L) and non-lesional skin (AD-NL) of atopic dermatitis patients. The differences between NS and AD-L and between NS and AD-NL were statistically significant (P<0.001, student t-test). The amount of cystatin A was 4.23±0.37μg (n=9) in control skin (NS) and 3.95±0.14μg (n=4) in AD-NL, but 2.13±0.22μg (n=16) in AD-L. The difference between NS and AD-L was statistically significant. The amount of involucrin was 3.31±0.57μg (n=10) in NS, 3.14±0.54μg (n=4) in AD-NL, 2.36±0.36μg (n=16) in AD-L. There were no statistically significant differences between either NS and AD-L or NS and AD-NL in amount of involucrin. These findings suggest that a decrease in the amount of filaggrin, which is the precursor protein for emollient factor (free amino acids) in the stratum corneum, may be one of the causes of dry skin in patients with atopic dermatitis. | |||||||||
| 言語 | en | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | 本文データはCiNiiから複製したものである。 | |||||||||
| 言語 | ja | |||||||||
