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虚血・再灌流心の心機能と心筋代謝に対するAcetylsalicylic Acidの心筋保護効果
https://kindai.repo.nii.ac.jp/records/2002011
https://kindai.repo.nii.ac.jp/records/2002011a8c55531-379c-40d9-b060-7590aef746f1
| 名前 / ファイル | ライセンス | アクション |
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AN00063584-19940325-0185.pdf (1021.8 KB)
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| Item type | ☆紀要論文 / Departmental Bulletin Paper(1) | |||||||||
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| 公開日 | 2024-11-15 | |||||||||
| タイトル | ||||||||||
| タイトル | 虚血・再灌流心の心機能と心筋代謝に対するAcetylsalicylic Acidの心筋保護効果 | |||||||||
| 言語 | ja | |||||||||
| タイトル | ||||||||||
| タイトル | Effect of acetylsalicylic acid on metabolism and contractility in the ischemic reperfused heart | |||||||||
| 言語 | en | |||||||||
| 著者 |
杉山, 和義
× 杉山, 和義
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| 言語 | ||||||||||
| 言語 | jpn | |||||||||
| キーワード | ||||||||||
| 主題 | ischemia, reperfusion, ^<31>P-NMR, acetylsalicylic acid, perfluorochemicals, high energy phosphate | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | departmental bulletin paper | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | AM | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||
| 出版者 名前 | ||||||||||
| 出版者 | 近畿大学医学会 | |||||||||
| 言語 | ja | |||||||||
| bibliographic_information |
ja : 近畿大学医学雑誌 en : Medical Journal of Kinki University 巻 19, 号 1, p. 185-201, 発行日 1994-03-25 |
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| ISSN | ||||||||||
| 収録物識別子タイプ | PISSN | |||||||||
| 収録物識別子 | 03858367 | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | The effect of acetylsalicylic acid (ASA) on high energy phosphates (adenosine triphosphate : ATP, creatine phosphate : CrP, inorganic phosphate : Pi) and intracellular pH during myocardial ischemia and reperfusion was studied with phosphorus 31-nuclear magnetic resonance (^<31>P-NMR) in the isolated rabbit hearts. Also, coronary flow and left ventricular systolic pressure (LVSP), left ventricular end-diastolic pressure (LVEDP) and left ventricular systolic developed pressure (LV Dev. P) were measured. Langendorff hearts perfused at 37℃ with perfluorochemical emulsion Fluosol-43 were subjected to 15 min and 30 min zero-flow ischemia and 15 min low-flow ischemia (coronary perfusion pressure=20 mmHg), following by 65 min of reperfusion (Group I). ASA (0.28 mM) was infused for the entire experimental period from 45 min prior to ischemia (Group II) and infused immediately after reperfusion (Group III). During ischemia, Group II showed a significant suppression of the decrease in ATP level and pH in both zero-flow and low-flow ischemia compared to that in other groups, moreover the increase of Pi and the decrease of CrP in low-flow ischemia was suppressed. In Group III, ATP level during reperfusion was significantly higher than Group I, but not significantly different from that in 30 min zero-flow ischemia. In 30 min zero-flow ischemia, Pi, CrP and coronary flow after reperfusion in Group II tended to recover to preischemic values. There were no differences in LV Dev. P among the 3 groups. In conclusion, ASA has a protective effect on myocardial high energy phosphates during ischemia and reperfusion in rabbit hearts. | |||||||||
| 言語 | en | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | 本文データはCiNiiから複製したものである。 | |||||||||
| 言語 | ja | |||||||||
