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気道攣縮時の肺循環動態：ネコ還流摘出肺における気道攣縮と低酸素負荷時の肺血管攣縮におよぼす交感神経遮断薬の影響
https://kindai.repo.nii.ac.jp/records/2002007
https://kindai.repo.nii.ac.jp/records/20020077bef9dab-8041-4a31-828d-b6d975c4975c
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AN00063584-19940325-0119.pdf (768.3 KB)
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| Item type | ☆紀要論文 / Departmental Bulletin Paper(1) | |||||||||
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| 公開日 | 2024-11-15 | |||||||||
| タイトル | ||||||||||
| タイトル | 気道攣縮時の肺循環動態：ネコ還流摘出肺における気道攣縮と低酸素負荷時の肺血管攣縮におよぼす交感神経遮断薬の影響 | |||||||||
| 言語 | ja | |||||||||
| タイトル | ||||||||||
| タイトル | Pulmonary circulation under bronchospasm : Effect of sympathetic nervous blockades on pulmonary vasoconstriction under bronchospasm and hypoxia on the isolated perfused cat lungs | |||||||||
| 言語 | en | |||||||||
| 著者 |
西村, 直己
× 西村, 直己
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| 言語 | ||||||||||
| 言語 | jpn | |||||||||
| キーワード | ||||||||||
| 主題 | isolated perfused cat lungs, hypoxic pulmonary vasoconstriction, bronchospasm, sympathetic nervous system | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | departmental bulletin paper | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | AM | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||
| 出版者 名前 | ||||||||||
| 出版者 | 近畿大学医学会 | |||||||||
| 言語 | ja | |||||||||
| bibliographic_information |
ja : 近畿大学医学雑誌 en : Medical Journal of Kinki University 巻 19, 号 1, p. 119-131, 発行日 1994-03-25 |
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| ISSN | ||||||||||
| 収録物識別子タイプ | PISSN | |||||||||
| 収録物識別子 | 03858367 | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | There are many reports about the correlation between the sympathetic nervous system and the hypoxic pulmonary vasoconstriction (HPV), but there are few reports about the sympathetic nervous system and the HPV when it is accompanied with bronchospasm as observed in bronchial asthma. The sympathetic nervous system has been considered to play a minor role on the HPV. In our study the β-blockade did not influence the HPV. Therefore, we studied about the role of the sympathetic nervous system for the HPV under bronchospasm, and tried to clarify the correlation of pulmonary circulation and ventilation on bronchial asthma fit with hypoxemia. In the isolated perfused cat lungs, we induced bronchospasms during ventilation with hypoxic gases. The bronchospasm was induced by injecting either histamine or acetylcholine into the trachea to avoid a specific response. Under this condition, we perfused the α_1-, α_2-, β_1- or β_2-blockade. The HPV under bronchospasm induced by histamine was attenuated by the non-selective β-blockade (propranolol), the β_1-blockade (acebutolol, metoprolol) and the β_2-blockade (butoxamine) equally. The HPV under the bronchospasm induced by acetylcholine was equally attenuated by acebutolol and metoprolol. The HPV under this condition was not attenuated by the α_1-blockade (prazosin) or the α_2-blockade (yohimbine). The HPV under the bronchospasm induced by either histamine or acetylcholine was attenuated by the β_1- or β_2-blockade, but was not attenuated by the α_1- or α_2-blockade. The β_1- and β_2-adrenoceptors have been suggested to increase the tonus of the pulmonary vessel under the condition of bronchospasm and hypoxia, but not the α_1-nor α_2-adrenoceptor. Thus differing from HPV which is not accompanied with bronchospasm, the β_1- and β_2-adrenoceptors may influence the HPV when accompanied with bronchospasm. These findings imply that the β_1- and β_2-adrenoceptors also influence the tonus of the pulmonary vessel of bronchial asthma when the attack is complicated with hypoxemia. | |||||||||
| 言語 | en | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | 本文データはCiNiiから複製したものである。 | |||||||||
| 言語 | ja | |||||||||
