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閉塞性黄疸時の内因性エンドトキシン血症ラットにおけるウルソデオキシコール酸静脈内投与の効果について
https://kindai.repo.nii.ac.jp/records/2002006
https://kindai.repo.nii.ac.jp/records/20020069f0bc1e6-23bb-49d2-84c0-721a702af9ec
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AN00063584-19940325-0109.pdf (482.8 KB)
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| Item type | ☆紀要論文 / Departmental Bulletin Paper(1) | |||||||||
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| 公開日 | 2024-11-15 | |||||||||
| タイトル | ||||||||||
| タイトル | 閉塞性黄疸時の内因性エンドトキシン血症ラットにおけるウルソデオキシコール酸静脈内投与の効果について | |||||||||
| 言語 | ja | |||||||||
| タイトル | ||||||||||
| タイトル | The protective effect of the intravenous administration of ursodeoxycholic acid against endogenous endotoxemia in obstructive jaundiced rats | |||||||||
| 言語 | en | |||||||||
| 著者 |
中谷, 公一
× 中谷, 公一
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| 言語 | ||||||||||
| 言語 | jpn | |||||||||
| キーワード | ||||||||||
| 主題 | obstructive jaundice, endotoxin, endogenous endotoxemia, ursodeoxycholic acid, bacterial translocation, fluorescein isothiocyanate | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | departmental bulletin paper | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | AM | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||
| 出版者 名前 | ||||||||||
| 出版者 | 近畿大学医学会 | |||||||||
| 言語 | ja | |||||||||
| bibliographic_information |
ja : 近畿大学医学雑誌 en : Medical Journal of Kinki University 巻 19, 号 1, p. 109-118, 発行日 1994-03-25 |
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| ISSN | ||||||||||
| 収録物識別子タイプ | PISSN | |||||||||
| 収録物識別子 | 03858367 | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | Endogenous endotoxemia, which is due to the facilitated bacterial translocation from intraluminal space of the gastrointestinal tract to portal vein in spite of the absence of a focus of infection, is possibly involved in poor biliary drainage of percutaneous transhepatic cholangiodrainage (PTCD) in the case of obstructive jaundice. Ursodeoxycholic acid (UDCA) is a bile acid, which is often orally used in the treatment of cholestasis. Herein, the protective effect of intravenous administration of UDCA against endotoxemia was determined by measuring the survival rate, endotoxin concentration in portal and peripheral veins, ATP content of rat liver and serum level of TNF-α. Endogenous endotoxemia in rats with obstructive jaundice induced by simultaneous administration of E. coli endotoxin orally at the dose of 5 mg/100 g body weight and lead acetate intravenously at the dose of 5 mg/100 g body weight following bile duct ligation for two weeks and recanaliculization thereafter according to the model of Bailey. UDCA administration at the dose of 0.05 μmol/100 g body weight/min improved the survival rate significantly. In the UDCA-treated group, the endotoxin concentration in the peripheral vein was significantly lower and ATP content was significantly recovered to the normal level. Conversely, the endotoxin concentration in the portal vein and serum level of TNF-α were not different between the UDCA-treated and saline-treated control rats. To investigate the mechanism of effect of UDCA on the secretion of endotoxin into bile, fluorescein isothiocyanate (FITC) labeled lipopolysaccharide (LPS) was administered via the portal vein and its concentration in bile was measured with a spectrophotofluorometer. A significant increase in the secretion of LPS into the bile was noticed in UDCA-treated rats, suggesting that the lower concentration of LPS in the peripheral vein in UDCA-treated rats depends on the increase in secretion of LPS into the bile. These findings demonstrate that intravenous administration of UDCA protects against endotoxemia in obstructive jaundice by activating the transport pathway of endotoxin across the hepatocytes into the bile but has no effect on Kupffer cells. Therefore, UDCA treatment may be beneficial in the case of poor biliary drainage of PTCD in obstructive jaundice. | |||||||||
| 言語 | en | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | 本文データはCiNiiから複製したものである。 | |||||||||
| 言語 | ja | |||||||||
