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滑膜線維芽細胞におけるIL-6産生におよぼすIL-1βおよび関節液の影響について
https://kindai.repo.nii.ac.jp/records/2002002
https://kindai.repo.nii.ac.jp/records/200200236a1438e-9c01-4115-b1cb-08a225bf4055
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AN00063584-19940325-0047.pdf (792.2 KB)
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| Item type | ☆紀要論文 / Departmental Bulletin Paper(1) | |||||||||
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| 公開日 | 2024-11-15 | |||||||||
| タイトル | ||||||||||
| タイトル | 滑膜線維芽細胞におけるIL-6産生におよぼすIL-1βおよび関節液の影響について | |||||||||
| 言語 | ja | |||||||||
| タイトル | ||||||||||
| タイトル | The effects of IL-1 beta and synovial fluid on the production of IL-6 by synovial fibroblasts | |||||||||
| 言語 | en | |||||||||
| 著者 |
貴島, 浩二
× 貴島, 浩二
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| 言語 | ||||||||||
| 言語 | jpn | |||||||||
| キーワード | ||||||||||
| 主題 | rheumatoid arthritis (RA), osteoarthritis (OA), synovial fibroblast, interleukin 6 (IL-6), gene expression | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | departmental bulletin paper | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | AM | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||
| 出版者 名前 | ||||||||||
| 出版者 | 近畿大学医学会 | |||||||||
| 言語 | ja | |||||||||
| bibliographic_information |
ja : 近畿大学医学雑誌 en : Medical Journal of Kinki University 巻 19, 号 1, p. 47-59, 発行日 1994-03-25 |
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| ISSN | ||||||||||
| 収録物識別子タイプ | PISSN | |||||||||
| 収録物識別子 | 03858367 | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | Interleukin 6 (IL-6) is a potent cytokine, the biological activities of which include the stimulation of immunoglobulin secretion, T cell activation, induction of the acute phase response, activation of megakaryocytes, and pyrogenicity. These biological activities are involved in the expression of symptoms in rheumatoid arthritis. In this study, the effects of interleukin 1 beta (IL-1β) and synovial fluid on the production of IL-6 and on the expression of IL-6 mRNA by synovial fibroblasts were tested. Cultures of fibroblast-like cells were established from synovial tissue from patients with rheumatoid arthritis (RA) and with osteoarthritis (OA). Exposure of these cells and normal skin fibroblasts to IL-1β increased IL-6 secretion. The supernatant from IL-1β stimulated RA synovial fibroblasts contained significantly higher levels of IL-6, as compared with OA synovial fibroblasts and normal skin fibroblasts. IL-6 gene expression was studied in synovial fibroblasts representative of each disease state and normal skin fibroblasts using oligonucleotide probes specific for human IL-6. IL-6 mRNA expression increased by culturing synovial fibroblasts and normal skin fibroblasts in the presence of IL-1β (5 ng/ml). Significantly higher expression of IL-6 mRNA was observed in RA synovial fibroblasts than OA synovial fibroblasts and skin fibroblasts. Next, the effects of synovial fluids obtained from patients with RA and OA on the expression of IL-6 mRNA in synovial fibroblasts were examined. RA synovial fluid markedly enhanced the expression of IL-6 mRNA in RA synovial fibroblasts, and also slightly enhanced it in OA synovial fibroblasts. By contrast, OA synovial fluid less enhanced the expression of IL-6 mRNA only in RA synovial fibroblasts. These findings indicated that the upregulation of production of IL-6 by synovial fibroblasts may contribute to the perpetuation of joint inflammation in RA. | |||||||||
| 言語 | en | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | 本文データはCiNiiから複製したものである。 | |||||||||
| 言語 | ja | |||||||||
