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ラット毛細胆管側肝細胞膜における胆汁酸の一次性能動輸送について
https://kindai.repo.nii.ac.jp/records/2001999
https://kindai.repo.nii.ac.jp/records/2001999ef6b06ab-adcd-44d4-8f29-b839b9f3a8de
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AN00063584-19940325-0001.pdf (743.8 KB)
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| Item type | ☆紀要論文 / Departmental Bulletin Paper(1) | |||||||||
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| 公開日 | 2024-11-15 | |||||||||
| タイトル | ||||||||||
| タイトル | ラット毛細胆管側肝細胞膜における胆汁酸の一次性能動輸送について | |||||||||
| 言語 | ja | |||||||||
| タイトル | ||||||||||
| タイトル | The primary active transport of bile acid in rat liver canalicular membrane vesicles | |||||||||
| 言語 | en | |||||||||
| 著者 |
北野, 元一
× 北野, 元一
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| 言語 | ||||||||||
| 言語 | jpn | |||||||||
| キーワード | ||||||||||
| 主題 | bile acid, transport, canalicular membrane vesicles, ATP, taurocholate | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | departmental bulletin paper | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | AM | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||
| 出版者 名前 | ||||||||||
| 出版者 | 近畿大学医学会 | |||||||||
| 言語 | ja | |||||||||
| bibliographic_information |
ja : 近畿大学医学雑誌 en : Medical Journal of Kinki University 巻 19, 号 1, p. 1-14, 発行日 1994-03-25 |
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| ISSN | ||||||||||
| 収録物識別子タイプ | PISSN | |||||||||
| 収録物識別子 | 03858367 | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | ATP-dependent primary active transport of bile acid was studied by using taurocholate, the major bile acid in humans and rats, in vesicles enriched in rat liver canalicular plasma membranes. Incubation of canalicular membrane vesicles with taurocholate in the presence of ATP and magnesium ion (Mg^<2+>), resulted in a stimulated uptake of taurocholate into the vesicles. An increase in the Mg^<2+> concentration from 100 μmol/l to 10 mmol/l in the presence of 1 mmol/l ATP and ATP-regenerating system, caused an increase in the taurocholate uptake to the level of saturation in a concentration dependent manner (Km=400 μmol/l). Replacement of Mg^<2+> with the same concentration of manganese ion, cobalt ion and cadmium ion, caused a decrease in ATP-dependent taurocholate transport to 70%, 38% and 53%, respectively. Other bile acids such as glycocholic acid and taurodeoxycholic acid had dose-dependent inhibitory effects on ATP-dependent active transport of taurocholate, but non-bile acid organic anions such as glutathione and cefpiramide had only weak or no inhibitory effects. Sulfated bile acids such as taurolithoclolic acid 3-O-sulfate inhibited ATP-dependent taurocholate transport competitivelv (Ki=23 μmol/l), which was in contradiction to the hypothesis that separate transport systems in the rat liver exist for biliary secretion of sulfated and unsulfated bile acids. | |||||||||
| 言語 | en | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | 本文データはCiNiiから複製したものである。 | |||||||||
| 言語 | ja | |||||||||
