{"created":"2024-11-08T07:05:15.247662+00:00","id":2001985,"links":{},"metadata":{"_buckets":{"deposit":"7f662d93-e225-4d5d-ba64-26152f808535"},"_deposit":{"created_by":42,"id":"2001985","owners":[42],"pid":{"revision_id":0,"type":"depid","value":"2001985"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:02001985","sets":["14:2667:1728522335637:1728528474285"]},"author_link":[],"item_1693378644159":{"attribute_name":"研究分担者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"34419","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"寺村, 岳士","creatorNameLang":"ja"},{"creatorName":"Teramura, Takeshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"40460901","nameIdentifierScheme":"e-Rad"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"34419","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"竹原, 俊幸","creatorNameLang":"ja"},{"creatorName":"Takehara, Toshiyuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"60580561","nameIdentifierScheme":"e-Rad"}]}]},"item_1693381679919":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"=資源タイプ識別子":"http://purl.org/coar/resource_type/c_93fc","resourcetype":"report","resourceuri":"http://purl.org/coar/resource_type/c_93fc"}]},"item_30001_bibliographic_information17":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicNumberOfPages":"6","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2023)","bibliographic_titleLang":"ja"}]}]},"item_30001_creator2":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"34419","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"森, 樹史","creatorNameLang":"ja"},{"creatorName":"Mori, Tatsufumi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"40760492","nameIdentifierScheme":"e-Rad_Researcher"}]}]},"item_30001_description8":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"間葉系幹細胞は優れたサイトカイン産生能力と分化能力を有することから様々な疾患に対する再生医療材料として注目されている。一方で、MSCの未分化性や分化多能性、増殖といった幹細胞としての性質がどのように成立し維持されているのかはわかっていない。これまでの研究によりMSCのステムネスに関わる重要な転写因子としてTwist1が関与していることがわかった。本研究ではTwist1の詳細な制御機構の解明とin vivoにおけるTwist1を過剰発現したMSCの効果について検討を行い、肺線維症モデルマウスの治療効果について明らかにした。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"MSCs are somatic stem cells can isolated from various connective tissues such as bone marrow, fat, and synovial membrane. Because of its properties of cytokine secretion, multiple differentiation and niche formation, MSCs has been an attractive cell source for cell transplantation therapy. On the other hand, molecular mechanisms regulating stemness of the MSCs is largely unknown. Previous studies have implicated Twist1 as an important transcription factor involved in MSC stemness. In this study, we elucidated the detailed regulatory mechanism of Twist1 and examined the effects of MSCs overexpressing Twist1 in vivo to elucidate the therapeutic effects in a mouse model of pulmonary fibrosis.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"研究分野：細胞生物学","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_30001_file22":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"21K09263seika.pdf","filesize":[{"value":"457.8 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://kindai.repo.nii.ac.jp/record/2001985/files/21K09263seika.pdf"},"version_id":"0e2cc6e5-24ca-4461-86e3-b268a75dcecf"}]},"item_30001_funding_reference15":{"attribute_name":"助成情報","attribute_value_mlt":[{"subitem_award_numbers":{"subitem_award_number":"21K09263","subitem_award_uri":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K09263/"},"subitem_award_titles":[{"subitem_award_title":"転写因子TWIST1による分化転換と未分化性誘導を利用した間葉系幹細胞の作製","subitem_award_title_language":"ja"},{"subitem_award_title":"Creation of mesenchymal stem cells using transdifferentiation and undifferentiated induction by the transcription factor TWIST1","subitem_award_title_language":"en"}],"subitem_funder_names":[{"subitem_funder_name":"独立行政法人日本学術振興会","subitem_funder_name_language":"ja"},{"subitem_funder_name":"Japan Society for the Promotion of Science","subitem_funder_name_language":"en"}]}]},"item_30001_language10":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_30001_subject7":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"間葉系幹細胞","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"Twist1","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_30001_title0":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"転写因子TWIST1による分化転換と未分化性誘導を利用した間葉系幹細胞の作製","subitem_title_language":"ja"},{"subitem_title":"Creation of mesenchymal stem cells using transdifferentiation and undifferentiated induction by the transcription factor TWIST1","subitem_title_language":"en"}]},"item_30001_version_type12":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_title":"転写因子TWIST1による分化転換と未分化性誘導を利用した間葉系幹細胞の作製","item_type_id":"40001","owner":"42","path":["1728528474285"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-11-08"},"publish_date":"2024-11-08","publish_status":"0","recid":"2001985","relation_version_is_last":true,"title":["転写因子TWIST1による分化転換と未分化性誘導を利用した間葉系幹細胞の作製"],"weko_creator_id":"42","weko_shared_id":-1},"updated":"2024-12-09T05:52:18.330902+00:00"}