{"created":"2024-11-08T07:05:10.569218+00:00","id":2001984,"links":{},"metadata":{"_buckets":{"deposit":"1a0b44a9-fc2e-485c-835c-8df1a3fbbc53"},"_deposit":{"created_by":42,"id":"2001984","owners":[42],"pid":{"revision_id":0,"type":"depid","value":"2001984"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:02001984","sets":["14:2667:1728522335637:1728528474285"]},"author_link":[],"item_1693378644159":{"attribute_name":"研究分担者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"14501","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"神戸大学","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"山下, 公大","creatorNameLang":"ja"},{"creatorName":"Yamashita, Kimihiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"80535427","nameIdentifierScheme":"e-Rad"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"34306","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"京都薬科大学","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"中田, 晋","creatorNameLang":"ja"},{"creatorName":"Nakata, Susumu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"80590695","nameIdentifierScheme":"e-Rad"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"34401","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"大阪医科薬科大学","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"宮武, 伸一","creatorNameLang":"ja"},{"creatorName":"Miyatake, Shin-Ichi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"90209916","nameIdentifierScheme":"e-Rad"}]}]},"item_1693381679919":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"=資源タイプ識別子":"http://purl.org/coar/resource_type/c_93fc","resourcetype":"report","resourceuri":"http://purl.org/coar/resource_type/c_93fc"}]},"item_30001_bibliographic_information17":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicNumberOfPages":"11","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2023)","bibliographic_titleLang":"ja"}]}]},"item_30001_creator2":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"34419","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"藤田, 貢","creatorNameLang":"ja"},{"creatorName":"Fujita, Mitsugu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"40609997","nameIdentifierScheme":"e-Rad_Researcher"}]}]},"item_30001_description8":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"放射線療法の発展により悪性脳腫瘍グリオーマの生存期間が延長する一方、遅発性脳放射線壊死が問題となっている。研究では、放射線脳壊死マウスモデルを用いてM2マクロファージの集積と免疫抑制性分子の発現増加を確認し、これらが脳浮腫に関与することを明らかにした。また次世代シークエンサーを用いた腸内細菌叢解析により、クロストリジア目が脳放射線壊死に関連する免疫応答の強度と相関することを示した。さらにM2マクロファージを除去することでマウスの生存日数が延長することを確認した。これらの結果から、脳放射線壊死の悪化にはM2マクロファージと腸内細菌が関与していることが示唆された。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"This study aimed to analyze the function of M2 macrophages associated with radiation-induced brain necrosis using bioinformatics methods. In the treatment of gliomas, while advancements in chemotherapy and radiotherapy have extended survival times, the incidence of delayed radiation injuries, including brain necrosis, has also increased. The study confirmed the accumulation of M2 macrophages and the increased expression of immunosuppressive molecules (B7-H3, B7-H5) in radiation-induced brain necrosis mouse models, indicating their involvement in brain edema. Additionally, next-generation sequencing analysis of the gut microbiota revealed a correlation between Clostridia and the intensity of immune responses related to brain radiation necrosis. The removal of M2 macrophages significantly extended the survival time of mice. These results suggest that M2 macrophages infiltrating the tissue and metabolites produced by gut bacteria contribute to the exacerbation of brain radiation necrosis.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"研究分野：脳腫瘍","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_30001_file22":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"21K09167seika.pdf","filesize":[{"value":"502.6 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://kindai.repo.nii.ac.jp/record/2001984/files/21K09167seika.pdf"},"version_id":"c9151630-9576-4cc5-838b-50bc73fb7426"}]},"item_30001_funding_reference15":{"attribute_name":"助成情報","attribute_value_mlt":[{"subitem_award_numbers":{"subitem_award_number":"21K09167","subitem_award_uri":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K09167/"},"subitem_award_titles":[{"subitem_award_title":"バイオインフォマティクス的手法による放射線脳壊死関連M2マクロファージの機能解析","subitem_award_title_language":"ja"},{"subitem_award_title":"Functional analysis of radiation brain necrosis-associated M2 macrophages by bioinformatics methods.","subitem_award_title_language":"en"}],"subitem_funder_names":[{"subitem_funder_name":"独立行政法人日本学術振興会","subitem_funder_name_language":"ja"},{"subitem_funder_name":"Japan Society for the Promotion of Science","subitem_funder_name_language":"en"}]}]},"item_30001_language10":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_30001_subject7":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"グリオーマ","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"放射線脳壊死","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"マクロファージ","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"免疫抑制性分子","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"腸内細菌叢","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"慢性炎症","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_30001_title0":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"バイオインフォマティクス的手法による放射線脳壊死関連M2マクロファージの機能解析","subitem_title_language":"ja"},{"subitem_title":"Functional analysis of radiation brain necrosis-associated M2 macrophages by bioinformatics methods.","subitem_title_language":"en"}]},"item_30001_version_type12":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_title":"バイオインフォマティクス的手法による放射線脳壊死関連M2マクロファージの機能解析","item_type_id":"40001","owner":"42","path":["1728528474285"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-11-08"},"publish_date":"2024-11-08","publish_status":"0","recid":"2001984","relation_version_is_last":true,"title":["バイオインフォマティクス的手法による放射線脳壊死関連M2マクロファージの機能解析"],"weko_creator_id":"42","weko_shared_id":-1},"updated":"2024-12-09T05:52:17.608860+00:00"}