{"created":"2024-11-08T07:05:05.971854+00:00","id":2001983,"links":{},"metadata":{"_buckets":{"deposit":"8535b5d0-6a0a-4738-be36-bb4a11619d90"},"_deposit":{"created_by":42,"id":"2001983","owners":[42],"pid":{"revision_id":0,"type":"depid","value":"2001983"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:02001983","sets":["14:2667:1728522335637:1728528474285"]},"author_link":[],"item_1693378644159":{"attribute_name":"研究分担者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"34419","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"馬場谷, 成","creatorNameLang":"ja"},{"creatorName":"Babaya, Naru","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"10449837","nameIdentifierScheme":"e-Rad"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"34419","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"武友, 保憲","creatorNameLang":"ja"},{"creatorName":"Taketomo, Yasunori","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"20580591","nameIdentifierScheme":"e-Rad"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"34419","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"廣峰, 義久","creatorNameLang":"ja"},{"creatorName":"Hiromine, Yoshihisa","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"30460851","nameIdentifierScheme":"e-Rad"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"34419","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"能宗, 伸輔","creatorNameLang":"ja"},{"creatorName":"Noso, Shinsuke","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"90460849","nameIdentifierScheme":"e-Rad"}]}]},"item_1693381679919":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"=資源タイプ識別子":"http://purl.org/coar/resource_type/c_93fc","resourcetype":"report","resourceuri":"http://purl.org/coar/resource_type/c_93fc"}]},"item_30001_bibliographic_information17":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicNumberOfPages":"13","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2023)","bibliographic_titleLang":"ja"}]}]},"item_30001_creator2":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"34419","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"池上, 博司","creatorNameLang":"ja"},{"creatorName":"Ikegami, Hiroshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"20221062","nameIdentifierScheme":"e-Rad_Researcher"}]}]},"item_30001_description8":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"膵β細胞機能の完全廃絶を規定する遺伝因子を明らかにするとともに、そのバイオマーカーを同定して予知・予防・根治に役立てることを目的に、ゲノムワイド関連解析（GWAS)、メタボローム解析などを駆使して研究を進めた。1型糖尿病のGWASで同定した新規遺伝子座の1つCSADは。ヒト末梢血メタボローム解析で同定した膵β細胞破壊の急性期バイオマーカーHypotaurineを中間代謝産物とするタウリン合成系の鍵酵素であり、異なるアプローチ（遺伝解析とメタボローム解析）によって同一パスウエイが同定されたことは、タウリン合成系が膵β細胞破壊の阻止における重要な標的パスウエイであることを示している。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"Genetic basis of and biomarkers for complete destruction of pancreatic beta-cells was studied to obtain basic information of complete destruction of beta-cells to establish effective methods for prevention and intervention of type 1 diabetes. Several loci with genome-wide significance were identified by the genome-wide association study (GWAS). Metabolome analysis in peripheral blood identified several metabolites discriminating acute vs chronic phases and complete abolishment vs minimal residual function of beta cells. In particular, hypotaurine was found to be a biomarker of ongoing beta-cell destruction in acute phase of type 1 diabetes. Hypotaurine is an intermediate metabolite in taurine synthesis, whose key enzyme, CSAD, was identified as a gene for fulminant type 1 diabetes by GWAS, indicating that the same taurine synthesis pathway identified through different approach, GWAS and metabolome analysis, is a promissive target for prevention and intervention of type 1 diabetes.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"研究分野：糖尿病学","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_30001_file22":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"21K08589seika.pdf","filesize":[{"value":"228.5 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://kindai.repo.nii.ac.jp/record/2001983/files/21K08589seika.pdf"},"version_id":"14afe0c8-b0ee-4233-b135-634f7060c69a"}]},"item_30001_funding_reference15":{"attribute_name":"助成情報","attribute_value_mlt":[{"subitem_award_numbers":{"subitem_award_number":"21K08589","subitem_award_uri":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K08589/"},"subitem_award_titles":[{"subitem_award_title":"膵β細胞機能の完全廃絶を規定する遺伝因子ならびにバイオマーカーの同定と解析","subitem_award_title_language":"ja"},{"subitem_award_title":"Genetic basis of and biomarker for complete destruction of beta-cells in type 1 diabetes","subitem_award_title_language":"en"}],"subitem_funder_names":[{"subitem_funder_name":"独立行政法人日本学術振興会","subitem_funder_name_language":"ja"},{"subitem_funder_name":"Japan Society for the Promotion of Science","subitem_funder_name_language":"en"}]}]},"item_30001_language10":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_30001_subject7":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"1型糖尿病","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"遺伝因子","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"ゲノムワイド関連解析","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"メタボローム解析","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"バイオマーカー","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"膵β細胞","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"完全廃絶","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_30001_title0":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"膵β細胞機能の完全廃絶を規定する遺伝因子ならびにバイオマーカーの同定と解析","subitem_title_language":"ja"},{"subitem_title":"Genetic basis of and biomarker for complete destruction of beta-cells in type 1 diabetes","subitem_title_language":"en"}]},"item_30001_version_type12":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_title":"膵β細胞機能の完全廃絶を規定する遺伝因子ならびにバイオマーカーの同定と解析","item_type_id":"40001","owner":"42","path":["1728528474285"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-11-08"},"publish_date":"2024-11-08","publish_status":"0","recid":"2001983","relation_version_is_last":true,"title":["膵β細胞機能の完全廃絶を規定する遺伝因子ならびにバイオマーカーの同定と解析"],"weko_creator_id":"42","weko_shared_id":-1},"updated":"2024-12-09T05:52:16.783875+00:00"}