{"created":"2024-11-08T07:04:56.254615+00:00","id":2001981,"links":{},"metadata":{"_buckets":{"deposit":"9dcff895-4a61-463a-b559-b6003c9f1b8a"},"_deposit":{"created_by":42,"id":"2001981","owners":[42],"pid":{"revision_id":0,"type":"depid","value":"2001981"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:02001981","sets":["14:2667:1728522335637:1728528474285"]},"author_link":[],"item_1693378644159":{"attribute_name":"研究分担者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"34419","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"池上, 博司","creatorNameLang":"ja"},{"creatorName":"Ikegami, Hiroshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"20221062","nameIdentifierScheme":"e-Rad"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"34419","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"廣峰, 義久","creatorNameLang":"ja"},{"creatorName":"Hiromine, Yoshihisa","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"30460851","nameIdentifierScheme":"e-Rad"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"34419","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"能宗, 伸輔","creatorNameLang":"ja"},{"creatorName":"Noso, Shinsuke","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"90460849","nameIdentifierScheme":"e-Rad"}]}]},"item_1693381679919":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"=資源タイプ識別子":"http://purl.org/coar/resource_type/c_93fc","resourcetype":"report","resourceuri":"http://purl.org/coar/resource_type/c_93fc"}]},"item_30001_bibliographic_information17":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicNumberOfPages":"11","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2023)","bibliographic_titleLang":"ja"}]}]},"item_30001_creator2":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"34419","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"馬場谷, 成","creatorNameLang":"ja"},{"creatorName":"Babaya, Naru","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"10449837","nameIdentifierScheme":"e-Rad_Researcher"}]}]},"item_30001_description8":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"量的形質遺伝子座(QTL)マッピング解析により、マウス染色体(Chr)1、Chr4、Chr10に3つの新規糖尿病遺伝子座（Nidd5nsy、Nidd6nsy、Nidd1c3h）を同定した。これらの遺伝子座の影響は年齢依存的であり、それぞれのQTLが加齢によって異なる影響を受けることを示している。また、コンジェニック解析により、Nidd5nsyが糖尿病、インスリン抵抗性、内臓脂肪型肥満の原因となる遺伝子座であると証明した。ヒトを対象とした糖尿病研究では、膵部分切除術後の糖尿病発症率とその予測因子の解析や、内蔵アルゴリズムの異なる持続血糖モニタリング装置の出力データ比較などを行い報告した。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"Quantitative trait locus (QTL) mapping analysis identified three novel diabetes loci (Nidd5nsy, Nidd6nsy, and Nidd1c3h) on mouse chromosomes (Chr) 1, Chr4, and Chr10, respectively. The effects of these loci are age-dependent, indicating that each QTL is differentially affected by aging. Congenic analysis also showed that Nidd5nsy on Chr1 is a causal locus for diabetes, insulin resistance, and visceral adipose obesity. Diabetes studies in human subjects included case reports and research reports. For example, the incidence of diabetes and its predictors after partial pancreatectomy (pancreatoduodenectomy and pancreaticoduodenectomy), and differences in output data from continuous glucose monitoring (CGM) devices with different built-in algorithms were analyzed.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"研究分野：糖尿病学","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_30001_file22":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"21K08539seika.pdf","filesize":[{"value":"155.5 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://kindai.repo.nii.ac.jp/record/2001981/files/21K08539seika.pdf"},"version_id":"eb507590-646f-40c4-b1d6-5e41cdf0c3a3"}]},"item_30001_funding_reference15":{"attribute_name":"助成情報","attribute_value_mlt":[{"subitem_award_numbers":{"subitem_award_number":"21K08539","subitem_award_uri":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K08539/"},"subitem_award_titles":[{"subitem_award_title":"2型糖尿病における複合遺伝形質の分割とエピスタシス・エピジェネティクス解析","subitem_award_title_language":"ja"},{"subitem_award_title":"Subdivision of complex genetic traits and epistasis/epigenetics analysis in type 2 diabetes","subitem_award_title_language":"en"}],"subitem_funder_names":[{"subitem_funder_name":"独立行政法人日本学術振興会","subitem_funder_name_language":"ja"},{"subitem_funder_name":"Japan Society for the Promotion of Science","subitem_funder_name_language":"en"}]}]},"item_30001_language10":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_30001_subject7":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"NSYマウス","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"2型糖尿病","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"疾患感受性遺伝子","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"エピスタシス","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"エピジェネティクス","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_30001_title0":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"2型糖尿病における複合遺伝形質の分割とエピスタシス・エピジェネティクス解析","subitem_title_language":"ja"},{"subitem_title":"Subdivision of complex genetic traits and epistasis/epigenetics analysis in type 2 diabetes","subitem_title_language":"en"}]},"item_30001_version_type12":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_title":"2型糖尿病における複合遺伝形質の分割とエピスタシス・エピジェネティクス解析","item_type_id":"40001","owner":"42","path":["1728528474285"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-11-08"},"publish_date":"2024-11-08","publish_status":"0","recid":"2001981","relation_version_is_last":true,"title":["2型糖尿病における複合遺伝形質の分割とエピスタシス・エピジェネティクス解析"],"weko_creator_id":"42","weko_shared_id":-1},"updated":"2024-12-09T05:52:17.178272+00:00"}