{"created":"2024-11-08T07:04:51.934544+00:00","id":2001980,"links":{},"metadata":{"_buckets":{"deposit":"46ffefb0-fff3-4f8e-a83c-511cd94f1594"},"_deposit":{"created_by":42,"id":"2001980","owners":[42],"pid":{"revision_id":0,"type":"depid","value":"2001980"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:02001980","sets":["14:2667:1728522335637:1728528474285"]},"author_link":[],"item_1693378644159":{"attribute_name":"研究分担者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"34419","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"西田, 直生志","creatorNameLang":"ja"},{"creatorName":"Nishida, Naoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"60281755","nameIdentifierScheme":"e-Rad"}]}]},"item_1693381679919":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"=資源タイプ識別子":"http://purl.org/coar/resource_type/c_93fc","resourcetype":"report","resourceuri":"http://purl.org/coar/resource_type/c_93fc"}]},"item_30001_bibliographic_information17":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicNumberOfPages":"19","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2023)","bibliographic_titleLang":"ja"}]}]},"item_30001_creator2":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"34419","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"工藤, 正俊","creatorNameLang":"ja"},{"creatorName":"Kudo, Masatoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"10298953","nameIdentifierScheme":"e-Rad_Researcher"}]}]},"item_30001_description8":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"肝癌根治術後アジュバントで免疫チェックポイント阻害剤 (ICI) が投与された例で、術後circulating tumor DNA (ctDNA) と再発の関連を検討した。変異10copy/ml以上をctDNA陽性とし、腫瘍の免疫関連、β-catenin経路関連分子を検討、β-catenin活性化と非活性化群、TIME-hot/exhausted型とold/Treg型に分類した。無再発生存期間 (RFS) はβ-catenin非活性化、hot/exhausted型で有意に長く、ctDNA陽性例はRFSが短い傾向にあった。β-catenin経路遺伝子座位にコピー数変化陽性例はRFSが有意に短かかった。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"We investigated the association between the circulating tumor DNA (ctDNA) in postoperative plasma and recurrence in 32 patients who received adjuvant immune checkpoint inhibitors (ICIs) after radical hepatocellular carcinoma (HCC) surgery. A valiant of 10 copies/ml or more was considered as ctDNA positive. Tumor immune microenvironment (TIME) was classified by examining immune-related molecules and β-catenin-associated molecules. Patients were classified into 2 groups (β-catenin pathway activated and inactivated), and TIME-hot/exhausted and cold/Treg types). Postoperative recurrence-free survival (RFS) on ICI was significantly longer in the β -catenin pathway inactivation group and in the hot/exhausted TIME group. The median RFS for ctDNA-positive cases was 26.2 months and NR for ctDNA-negative cases, with a trend toward shorter RFS in ctDNA-positive cases. The cases with copy number variation on the β-catenin-related loci showed significantly shorter RFS under ICI treatment.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"研究分野：消化器内科","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_30001_file22":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"21K07950seika.pdf","filesize":[{"value":"594.2 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://kindai.repo.nii.ac.jp/record/2001980/files/21K07950seika.pdf"},"version_id":"bc94c29e-8173-4a4f-87e0-9aaf52966b53"}]},"item_30001_funding_reference15":{"attribute_name":"助成情報","attribute_value_mlt":[{"subitem_award_numbers":{"subitem_award_number":"21K07950","subitem_award_uri":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K07950/"},"subitem_award_titles":[{"subitem_award_title":"血中cfDNAを用いた肝細胞癌の化学療法に対する治療抵抗性クローンの同定","subitem_award_title_language":"ja"},{"subitem_award_title":"Identification of resistant clone for the chemotherapy of hepatocellular carcinoma using cell free DNA","subitem_award_title_language":"en"}],"subitem_funder_names":[{"subitem_funder_name":"独立行政法人日本学術振興会","subitem_funder_name_language":"ja"},{"subitem_funder_name":"Japan Society for the Promotion of Science","subitem_funder_name_language":"en"}]}]},"item_30001_language10":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_30001_subject7":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"肝細胞癌","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"免疫チェックポイント阻害剤","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"アジュバント療法","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"腫瘍免疫微小環境","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"cell-free DNA","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"ドライバー変異","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_30001_title0":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"血中cfDNAを用いた肝細胞癌の化学療法に対する治療抵抗性クローンの同定","subitem_title_language":"ja"},{"subitem_title":"Identification of resistant clone for the chemotherapy of hepatocellular carcinoma using cell free DNA","subitem_title_language":"en"}]},"item_30001_version_type12":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_title":"血中cfDNAを用いた肝細胞癌の化学療法に対する治療抵抗性クローンの同定","item_type_id":"40001","owner":"42","path":["1728528474285"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-11-08"},"publish_date":"2024-11-08","publish_status":"0","recid":"2001980","relation_version_is_last":true,"title":["血中cfDNAを用いた肝細胞癌の化学療法に対する治療抵抗性クローンの同定"],"weko_creator_id":"42","weko_shared_id":-1},"updated":"2024-12-09T05:52:15.716218+00:00"}