{"created":"2024-11-08T07:04:42.550901+00:00","id":2001978,"links":{},"metadata":{"_buckets":{"deposit":"3bdbbc6c-3be6-485f-9141-54a5a44ec9fa"},"_deposit":{"created_by":42,"id":"2001978","owners":[42],"pid":{"revision_id":0,"type":"depid","value":"2001978"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:02001978","sets":["14:2667:1728522335637:1728528474285"]},"author_link":[],"item_1693381679919":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"=資源タイプ識別子":"http://purl.org/coar/resource_type/c_93fc","resourcetype":"report","resourceuri":"http://purl.org/coar/resource_type/c_93fc"}]},"item_30001_bibliographic_information17":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicNumberOfPages":"8","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2023)","bibliographic_titleLang":"ja"}]}]},"item_30001_creator2":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"34419","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"朴, 雅美","creatorNameLang":"ja"},{"creatorName":"Park, Ah-Mee","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"70469245","nameIdentifierScheme":"e-Rad_Researcher"}]}]},"item_30001_description8":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Helicobacter pylori （HP）は胃に持続感染し消化性潰瘍・胃癌を引き起こす病原菌であるが、胃外疾患との関連も多く、アルツハイマー型認知症（AD）ではHPの感染率が高いことが報告されている。本研究では動物モデルを用いてAD病態へのHP感染の影響とメカニズムの解明を目指した。HPを長期感染させた老齢ADマウスでは、脳でオートファジーや炎症に関連する遺伝子発現が増加すること、老人斑が減少することが分かった。HPが分泌する外膜小胞（OMV）は老齢マウスでのみ脳内に移行するが、OMVには中球活性化proteinなどが含まれており、これらが脳の炎症などに影響している可能性が示唆された。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"Helicobacter pylori (HP) is a pathogenic bacterium that chronically infects the stomach and causes peptic ulcers and gastric cancer. HP is also associated with extragastric diseases, and a high rate of HP infection has been reported in Alzheimer's disease (AD). In this study, we aimed to elucidate the effects and mechanisms of HP infection on AD pathology using an animal model. We found that mRNA expression related to autophagy and inflammation increased and amyloid plaques decreased in the brain of aged AD mice infected with HP for 10-months. OMVs contain neutrophil-activated protein, which may affect brain inflammation.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"研究分野：微生物学","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_30001_file22":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"21K07287seika.pdf","filesize":[{"value":"621.7 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://kindai.repo.nii.ac.jp/record/2001978/files/21K07287seika.pdf"},"version_id":"d0dbc59b-e74d-455e-be01-e794656732c6"}]},"item_30001_funding_reference15":{"attribute_name":"助成情報","attribute_value_mlt":[{"subitem_award_numbers":{"subitem_award_number":"21K07287","subitem_award_uri":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K07287/"},"subitem_award_titles":[{"subitem_award_title":"慢性胃粘膜感染したピロリ菌が分泌する外膜小胞による神経炎症の制御機構","subitem_award_title_language":"ja"},{"subitem_award_title":"Regulatory mechanisms of neuroinflammation by outer membrane vesicles secreted by chronically gastric mucosa-infected H. pylori.","subitem_award_title_language":"en"}],"subitem_funder_names":[{"subitem_funder_name":"独立行政法人日本学術振興会","subitem_funder_name_language":"ja"},{"subitem_funder_name":"Japan Society for the Promotion of Science","subitem_funder_name_language":"en"}]}]},"item_30001_language10":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_30001_subject7":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Helicobacter pylori","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"outer membrane vesicles","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"neuronal inflammation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Alzheimer's disease","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_30001_title0":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"慢性胃粘膜感染したピロリ菌が分泌する外膜小胞による神経炎症の制御機構","subitem_title_language":"ja"},{"subitem_title":"Regulatory mechanisms of neuroinflammation by outer membrane vesicles secreted by chronically gastric mucosa-infected H. pylori.","subitem_title_language":"en"}]},"item_30001_version_type12":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_title":"慢性胃粘膜感染したピロリ菌が分泌する外膜小胞による神経炎症の制御機構","item_type_id":"40001","owner":"42","path":["1728528474285"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-11-08"},"publish_date":"2024-11-08","publish_status":"0","recid":"2001978","relation_version_is_last":true,"title":["慢性胃粘膜感染したピロリ菌が分泌する外膜小胞による神経炎症の制御機構"],"weko_creator_id":"42","weko_shared_id":-1},"updated":"2024-12-09T05:52:16.128424+00:00"}