{"created":"2024-11-08T07:04:24.702615+00:00","id":2001974,"links":{},"metadata":{"_buckets":{"deposit":"6b02cd30-a3ef-4a19-94a5-bc2f25821a20"},"_deposit":{"created_by":42,"id":"2001974","owners":[42],"pid":{"revision_id":0,"type":"depid","value":"2001974"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:02001974","sets":["14:2667:1728522335637:1728528474285"]},"author_link":[],"control_number":"2001974","item_1693378644159":{"attribute_name":"研究分担者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"34419","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"西中, 崇","creatorNameLang":"ja"},{"creatorName":"Nishinaka, Takashi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"50786184","nameIdentifierScheme":"e-Rad"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"34419","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"高橋, 英夫","creatorNameLang":"ja"},{"creatorName":"Takahashi Hideo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"60335627","nameIdentifierScheme":"e-Rad"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"34419","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"和氣, 秀徳","creatorNameLang":"ja"},{"creatorName":"Wake, Hidenori","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"60570520","nameIdentifierScheme":"e-Rad"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"15301","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"岡山大学","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"西田, 圭一郎","creatorNameLang":"ja"},{"creatorName":"Nishida, Keiichiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"80284058","nameIdentifierScheme":"e-Rad"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"15301","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"岡山大学","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"廣畑, 聡","creatorNameLang":"ja"},{"creatorName":"Hirohata, Satoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"90332791","nameIdentifierScheme":"e-Rad"}]}]},"item_1693381679919":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"=資源タイプ識別子":"http://purl.org/coar/resource_type/c_93fc","resourcetype":"report","resourceuri":"http://purl.org/coar/resource_type/c_93fc"}]},"item_30001_bibliographic_information17":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicNumberOfPages":"12","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2023)","bibliographic_titleLang":"ja"}]}]},"item_30001_creator2":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"34419","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"ハティポール, オメル・ファルク","creatorNameLang":"ja"},{"creatorName":"Hatipoglu, Omer Faruk","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"90791765","nameIdentifierScheme":"e-Rad_Researcher"}]}]},"item_30001_description8":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"ヒト内皮細胞において、ヒスタミンがH1受容体を介して用量依存的に顕著な管腔形成を誘導することを見出した。このメカニズムとして、ヒスタミンによって誘導されたMMP9およびMMP14が細胞外マトリクスにトラップされたVEGFを解放し、VEGF-VEGFR2相互作用を促進することで管腔形成が誘導されることが明らかになった。また、ヒスタミンによる管腔形成にはサイトカインであるIL-33およびその受容体であるST2も重要な役割を果たしており、さらに血漿糖タンパク質であるHistidine-rich glycoprotein（HRG）がIL-33による管腔形成を抑制することも明らかにした。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"We have confirmed that histamine dose-dependently induces tube formation in human endothelial cells via the H1 receptor. The mechanism is that histamine-induced MMP9/MMP14 releases extracellular matrix-bound VEGF and promotes VEGF-VEGFR2 interaction, which in turn induces tube formation. We also found that the cytokine IL-33 and the IL-33 receptor ST2 also play important roles in histamine-induced tube formation, and that the plasma glycoprotein histidine-rich glycoprotein (HRG) inhibits IL-33-induced tube formation.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"研究分野：薬理学","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_30001_file22":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"21K06588seika.pdf","filesize":[{"value":"3.2 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://kindai.repo.nii.ac.jp/record/2001974/files/21K06588seika.pdf"},"version_id":"4e2cf5a6-4f3d-4226-9f53-623773e12f2b"}]},"item_30001_funding_reference15":{"attribute_name":"助成情報","attribute_value_mlt":[{"subitem_award_numbers":{"subitem_award_number":"21K06588","subitem_award_uri":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K06588/"},"subitem_award_titles":[{"subitem_award_title":"IL-33を標的とした 改善候補薬による恒常性維持効果の基礎的検討","subitem_award_title_language":"ja"},{"subitem_award_title":"Homeostatic effect of improvement candidate drug targeting IL-33","subitem_award_title_language":"en"}],"subitem_funder_names":[{"subitem_funder_name":"独立行政法人日本学術振興会","subitem_funder_name_language":"ja"},{"subitem_funder_name":"Japan Society for the Promotion of Science","subitem_funder_name_language":"en"}]}]},"item_30001_language10":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_30001_subject7":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"慢性炎症性疾患","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"血管新生","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"炎症生サイトカイン","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"血漿糖タンパク質","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"ヒスタミン","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_30001_title0":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"IL-33を標的とした改善候補薬による恒常性維持効果の基礎的検討","subitem_title_language":"ja"},{"subitem_title":"Homeostatic effect of improvement candidate drug targeting IL-33","subitem_title_language":"en"}]},"item_30001_version_type12":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_title":"IL-33を標的とした改善候補薬による恒常性維持効果の基礎的検討","item_type_id":"40001","owner":"42","path":["1728528474285"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-11-08"},"publish_date":"2024-11-08","publish_status":"0","recid":"2001974","relation_version_is_last":true,"title":["IL-33を標的とした改善候補薬による恒常性維持効果の基礎的検討"],"weko_creator_id":"42","weko_shared_id":-1},"updated":"2024-12-09T05:52:22.774216+00:00"}