{"created":"2024-11-08T07:03:41.957329+00:00","id":2001964,"links":{},"metadata":{"_buckets":{"deposit":"6abcff0b-74e7-4f62-a9b3-4ad071eb32b3"},"_deposit":{"created_by":42,"id":"2001964","owners":[42],"pid":{"revision_id":0,"type":"depid","value":"2001964"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:02001964","sets":["14:2667:1728522335637:1728528474285"]},"author_link":[],"item_1693378644159":{"attribute_name":"研究分担者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"33916","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"浜松医科大学","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"酒井, 康弘","creatorNameLang":"ja"},{"creatorName":"Sakai, Yasuhiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"20754394","nameIdentifierScheme":"e-Rad"}]}]},"item_1693381679919":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"=資源タイプ識別子":"http://purl.org/coar/resource_type/c_93fc","resourcetype":"report","resourceuri":"http://purl.org/coar/resource_type/c_93fc"}]},"item_30001_bibliographic_information17":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicNumberOfPages":"8","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2023)","bibliographic_titleLang":"ja"}]}]},"item_30001_creator2":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"34419","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"桑原, 一彦","creatorNameLang":"ja"},{"creatorName":"Kuwahara, Kazuhiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"10263469","nameIdentifierScheme":"e-Rad_Researcher"}]}]},"item_30001_description8":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"PARP阻害剤は現在抗がん治療に適応されており、BRCA1/2変異を有する癌でその有効性が認められており、乳癌、卵巣癌、膵癌などで臨床応用されている。BRCA変異は全乳癌患者の約5%でのみみられるため、大部分の非遺伝性散発性乳癌ではPARP阻害剤による治療効果は得られない。我々は非遺伝性散発性乳癌の発症に関わるGANPの発現抑制がBRCA2のタンパク発現を低下させることから、GANPの発現抑制によるPARP阻害剤の効果を示した。GANP発現低下によるBRCAness誘導に至る分子機構を利用し、BRCA変異の有無に依らないPARP阻害剤による新規乳癌治療戦略を提示した。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"Inhibitors of poly (ADP-ribose) polymerase (PARP) have emerged as a new class of anti-cancer drugs, specifically for malignancies bearing aberrations of the homologous recombination pathway. They are clinically used in breast, ovarian, and pancreatic cancers. BRCA mutations are observed only in 5% among the patients with breast cancers; therefore, PARP inhibitors are ineffective to most of the patients with non-hereditary sporadic breast cancers. We found that PARP inhibitors could suppress the proliferation of breast cancer cells after ganp knockdown. In breast cancer cells, we demonstrate a novel strategy by PARP inhibitors through BRCAness induced by GANP-deficiency.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"研究分野：実験病理","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_30001_file22":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"20K07686seika.pdf","filesize":[{"value":"91.2 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://kindai.repo.nii.ac.jp/record/2001964/files/20K07686seika.pdf"},"version_id":"9cdc3f2d-8bbd-42bb-96df-027357f9a281"}]},"item_30001_funding_reference15":{"attribute_name":"助成情報","attribute_value_mlt":[{"subitem_award_numbers":{"subitem_award_number":"20K07686","subitem_award_uri":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K07686/"},"subitem_award_titles":[{"subitem_award_title":"PARP阻害剤による非遺伝性乳癌に対する新規抗がん治療戦略","subitem_award_title_language":"ja"},{"subitem_award_title":"A novel strategy by PARP inhibitors for sporadic breast cancers","subitem_award_title_language":"en"}],"subitem_funder_names":[{"subitem_funder_name":"独立行政法人日本学術振興会","subitem_funder_name_language":"ja"},{"subitem_funder_name":"Japan Society for the Promotion of Science","subitem_funder_name_language":"en"}]}]},"item_30001_language10":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_30001_subject7":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"乳癌","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"転写共役型DNA傷害","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_30001_title0":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"PARP阻害剤による非遺伝性乳癌に対する新規抗がん治療戦略","subitem_title_language":"ja"},{"subitem_title":"A novel strategy by PARP inhibitors for sporadic breast cancers","subitem_title_language":"en"}]},"item_30001_version_type12":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_title":"PARP阻害剤による非遺伝性乳癌に対する新規抗がん治療戦略","item_type_id":"40001","owner":"42","path":["1728528474285"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-11-08"},"publish_date":"2024-11-08","publish_status":"0","recid":"2001964","relation_version_is_last":true,"title":["PARP阻害剤による非遺伝性乳癌に対する新規抗がん治療戦略"],"weko_creator_id":"42","weko_shared_id":-1},"updated":"2024-12-09T05:52:02.821332+00:00"}