{"created":"2024-10-24T05:34:26.659264+00:00","id":2001948,"links":{},"metadata":{"_buckets":{"deposit":"b0b1ae72-3eba-473e-9ec2-12a1a898d5f1"},"_deposit":{"created_by":42,"id":"2001948","owners":[42],"pid":{"revision_id":0,"type":"depid","value":"2001948"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:02001948","sets":["14:2667:1728522335637:1728523622287"]},"author_link":[],"item_1693381679919":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"=資源タイプ識別子":"http://purl.org/coar/resource_type/c_93fc","resourcetype":"report","resourceuri":"http://purl.org/coar/resource_type/c_93fc"}]},"item_30001_bibliographic_information17":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicNumberOfPages":"7","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2023)","bibliographic_titleLang":"ja"}]}]},"item_30001_creator2":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"34419","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"中澤, 直高","creatorNameLang":"ja"},{"creatorName":"Nakazawa, Naotaka","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"90800780","nameIdentifierScheme":"e-Rad_Researcher"}]}]},"item_30001_description8":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"本研究では、脳発生に関わる1)新生ニューロンの遊走、2)神経芽細胞や神経幹細胞の増殖・分化、に着目した。従来の生化学的・細胞生物学的手法や遺伝学的手法にマイクロデバイス流路を用いたイメージング手法を組み合わせることで、1)脳組織内を遊走するニューロンが細胞外環境からの圧刺激を検知することで外環境に応じた力学機構を発動させ、狭小な空間を通過する分子機構、2)細胞外環境からの圧刺激を受けた神経芽細胞およびその細胞核ではいくつかの遺伝子群の発現が変動すること、を明らかにした。さらに、脳組織に圧刺激を付加する新規の実験系を確立した。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"In this study, we focused on 1) cell migration of newborn neurons and 2) proliferation and differentiation of neuroblasts and neural stem cells, which are involved in brain development. By combining conventional biochemical, cell biological, and genetic methods with imaging techniques using a microfluidic device, we have identified 1) the molecular mechanisms of neuronal migration driven by pressure stimuli from the extracellular environment in confined brain tissue, 2) mechanical compression to neuroblasts and their nuclei alters gene expression. Furthermore, we established a novel experimental system to add pressure stimulation to brain tissue.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"研究分野：生体医工学","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_30001_file22":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"21H05126seika.pdf","filesize":[{"value":"1.9 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://kindai.repo.nii.ac.jp/record/2001948/files/21H05126seika.pdf"},"version_id":"5f9675cd-8067-4c4b-85c6-9ac445b10598"}]},"item_30001_funding_reference15":{"attribute_name":"助成情報","attribute_value_mlt":[{"subitem_award_numbers":{"subitem_award_number":"21H05126","subitem_award_uri":"https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-21H05126/"},"subitem_award_titles":[{"subitem_award_title":"脳脊髄液圧依存的な組織伸展と神経幹細胞への圧縮刺激による神経発生の調節機構の解明","subitem_award_title_language":"ja"},{"subitem_award_title":"Mechanisms of brain development by compressive stress on neural stem cells and brain tissue","subitem_award_title_language":"en"}],"subitem_funder_names":[{"subitem_funder_name":"独立行政法人日本学術振興会","subitem_funder_name_language":"ja"},{"subitem_funder_name":"Japan Society for the Promotion of Science","subitem_funder_name_language":"en"}]}]},"item_30001_language10":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_30001_subject7":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"神経発生","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"メカノバイオロジー","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"メカノレスポンス","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"神経細胞移動","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_30001_title0":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"脳脊髄液圧依存的な組織伸展と神経幹細胞への圧縮刺激による神経発生の調節機構の解明","subitem_title_language":"ja"},{"subitem_title":"Mechanisms of brain development by compressive stress on neural stem cells and brain tissue","subitem_title_language":"en"}]},"item_30001_version_type12":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_title":"脳脊髄液圧依存的な組織伸展と神経幹細胞への圧縮刺激による神経発生の調節機構の解明","item_type_id":"40001","owner":"42","path":["1728523622287"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-10-24"},"publish_date":"2024-10-24","publish_status":"0","recid":"2001948","relation_version_is_last":true,"title":["脳脊髄液圧依存的な組織伸展と神経幹細胞への圧縮刺激による神経発生の調節機構の解明"],"weko_creator_id":"42","weko_shared_id":-1},"updated":"2024-11-25T02:35:26.984417+00:00"}