{"created":"2024-10-24T05:31:56.427059+00:00","id":2001914,"links":{},"metadata":{"_buckets":{"deposit":"774a797b-5ab2-4d99-9fa6-e94f508ccbbd"},"_deposit":{"created_by":42,"id":"2001914","owners":[42],"pid":{"revision_id":0,"type":"depid","value":"2001914"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:02001914","sets":["14:2667:1728522335637:1728523622287"]},"author_link":[],"item_1693381679919":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"=資源タイプ識別子":"http://purl.org/coar/resource_type/c_93fc","resourcetype":"report","resourceuri":"http://purl.org/coar/resource_type/c_93fc"}]},"item_30001_bibliographic_information17":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicNumberOfPages":"8","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2023)","bibliographic_titleLang":"ja"}]}]},"item_30001_creator2":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"34419","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"森山, 博由","creatorNameLang":"ja"},{"creatorName":"Moriyama, Hiroyuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"90581124","nameIdentifierScheme":"e-Rad_Researcher"}]}]},"item_30001_description8":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"scRNA-seq解析の検索手法を再設定し数理学的にクラスター解析を高解像度化した。特定の終末細胞への分化指向性および液性因子等の分泌物質の特徴などの違いなど、特徴的な性状を示す亜集団細胞群を同定した。また、本解析系高詳細化した細亜集団を含めた多項間比較に特化したAI解析プログラムの開発に至った。また、真の幹細胞の性質に近づく知見として、CD34分子の増加や減弱そのタイミングにある種の法則があることを見出した。Pseudo-time解析から、少なくとも縮小集団は2系統の流れ（分化もしくは変容の方向性）に強く影響することも分かった。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"ScRNA-seq analysis methodology was revised, and resolution of 6 clusters was mathematically resolved to higher resolution. As a result, we identified subpopulations of cells that exhibit distinctive characteristics, including differences in differentiation directionality toward specific terminal cells and secretory characteristics, such as vacuolar factors. These results are expected to provide basic knowledge that will be useful for clinical applications. In addition, we have developed an AI analysis program specialized for multinomial comparisons including highly detailed subpopulations of this analysis system. Pseudo-time analysis also revealed that at least the shrinking population strongly influences the flow (direction of differentiation or transformation) of the two lineages.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"研究分野：幹細胞生物学","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_30001_file22":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"21K09783seika.pdf","filesize":[{"value":"237.9 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://kindai.repo.nii.ac.jp/record/2001914/files/21K09783seika.pdf"},"version_id":"f737ae79-fdd6-486f-ac5a-291d93222abb"}]},"item_30001_funding_reference15":{"attribute_name":"助成情報","attribute_value_mlt":[{"subitem_award_numbers":{"subitem_award_number":"21K09783","subitem_award_uri":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K09783/"},"subitem_award_titles":[{"subitem_award_title":"再生医療に資する質と量を担保できる真のヒト脂肪由来幹細胞の探求","subitem_award_title_language":"ja"},{"subitem_award_title":"Research for a genuine human adipose-derived stem cells source that can ensure quality and quantity capable for regenerative medicine","subitem_award_title_language":"en"}],"subitem_funder_names":[{"subitem_funder_name":"独立行政法人日本学術振興会","subitem_funder_name_language":"ja"},{"subitem_funder_name":"Japan Society for the Promotion of Science","subitem_funder_name_language":"en"}]}]},"item_30001_language10":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_30001_subject7":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"脂肪由来間葉系幹細胞","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"シングルセル解析","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"インフォマティクス解析","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"トランスクリプトーム解析","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"特異的マーカー","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"分化誘導","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"3Dプリンティング","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"組織構築","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_30001_title0":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"再生医療に資する質と量を担保できる真のヒト脂肪由来幹細胞の探求","subitem_title_language":"ja"},{"subitem_title":"Research for a genuine human adipose-derived stem cells source that can ensure quality and quantity capable for regenerative medicine","subitem_title_language":"en"}]},"item_30001_version_type12":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_title":"再生医療に資する質と量を担保できる真のヒト脂肪由来幹細胞の探求","item_type_id":"40001","owner":"42","path":["1728523622287"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-10-24"},"publish_date":"2024-10-24","publish_status":"0","recid":"2001914","relation_version_is_last":true,"title":["再生医療に資する質と量を担保できる真のヒト脂肪由来幹細胞の探求"],"weko_creator_id":"42","weko_shared_id":-1},"updated":"2024-11-25T02:35:34.473611+00:00"}