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小児腎疾患における血中Insulin-like Growth Factor Binding Protein-3および成長関連物質の動態
https://kindai.repo.nii.ac.jp/records/2001841
https://kindai.repo.nii.ac.jp/records/20018419c0ca67f-e9cb-4b04-8c7a-43b30e09e59f
| 名前 / ファイル | ライセンス | アクション |
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AN00063584-19950625-0071.pdf (1.1 MB)
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| Item type | ☆紀要論文 / Departmental Bulletin Paper(1) | |||||||||
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| 公開日 | 2024-10-09 | |||||||||
| タイトル | ||||||||||
| タイトル | 小児腎疾患における血中Insulin-like Growth Factor Binding Protein-3および成長関連物質の動態 | |||||||||
| 言語 | ja | |||||||||
| タイトル | ||||||||||
| タイトル | Characterization of Insulin-like Growth Factor Binding Protein-3 in human serum and other growth factors in children with various renal diseases | |||||||||
| 言語 | en | |||||||||
| 著者 |
石渡, 淳一
× 石渡, 淳一
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| 言語 | ||||||||||
| 言語 | jpn | |||||||||
| キーワード | ||||||||||
| 主題 | insulin-like growth factor (IGF-I), insulin-like growth factor binding protein-3 (BP3), unsaturated IGF-I binding protein (UBP) | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | departmental bulletin paper | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | AM | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||
| 出版者 名前 | ||||||||||
| 出版者 | 近畿大学医学会 | |||||||||
| 言語 | ja | |||||||||
| bibliographic_information |
ja : 近畿大学医学雑誌 en : Medical Journal of Kinki University 巻 20, 号 1, p. 71-86, 発行日 1995-06-25 |
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| ISSN | ||||||||||
| 収録物識別子タイプ | PISSN | |||||||||
| 収録物識別子 | 03858367 | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | An enzyme immunoassay (EIA) for the quantitative determination of insulin-like growth factor binding protein-3 (BP3) was established, and reported herein. BP3 was purified from pooled human serum by column chromatography with Superose^<TM>10/30, HiTrap Heparin and antibody bound Sepharose 4B. The molecular weights of the purified BP3 were 150 kD, 53 kD and 47 kD. The antigenicity of the purified BP3 was equal to that of the commercially obtained recombinant BP3. The growth rat cultured mesangial cells 10^4 mesangial cells per milliliter was accelerated by human recombinant IGF-I, with maximum acceleration obtained at 12.5ng/ml and inhibeted by human recombinant BP3 with maximum inhibition obtained 1.0mg/ml. The serum levels of BP3 in normal children were correlated to their serum levels of creatinine (R=0.61, p=0.004). However, there was a weak correlation between the serum levels of BP3 and those of creatinine in children with renal disease, whose serum creatinine levels exceeded 1.0mg/dl (R=0.493, p=0.123). The serum IGF-I levels were also correlated to those of creatinine in normal children, while there was no correlation between the levels of serum IGF-I and serum creatinine in children with renal diseases. The serum level of unsaturated IGF-I binding protein (UBP) decreased according with the decrease in the amount of excreted urinary protein (R=-0.361, p=0.118). | |||||||||
| 言語 | en | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | 本文データはCiNiiから複製したものである。 | |||||||||
| 言語 | ja | |||||||||
