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螢光in situハイブリダイゼーション法による高精度ヒト1番染色体短腕の細胞遺伝学的地図の作製と1p36.1領域のコスミッドマーカーの配列決定
https://kindai.repo.nii.ac.jp/records/2001836
https://kindai.repo.nii.ac.jp/records/20018360b2fe6bb-579d-4699-b2fa-b9186a0d98d2
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AN00063584-19950625-0001.pdf (1019.7 KB)
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| Item type | ☆紀要論文 / Departmental Bulletin Paper(1) | |||||||||
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| 公開日 | 2024-10-09 | |||||||||
| タイトル | ||||||||||
| タイトル | 螢光in situハイブリダイゼーション法による高精度ヒト1番染色体短腕の細胞遺伝学的地図の作製と1p36.1領域のコスミッドマーカーの配列決定 | |||||||||
| 言語 | ja | |||||||||
| タイトル | ||||||||||
| タイトル | Construction of high-resolution cytogenetic map of the short arm of human chromosome 1 bearing the precise ordering of 18 DNA markers on 1p36.1 using fluorescence in situ hybridization | |||||||||
| 言語 | en | |||||||||
| 著者 |
有山, 武志
× 有山, 武志
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| 言語 | ||||||||||
| 言語 | jpn | |||||||||
| キーワード | ||||||||||
| 主題 | cytogenetic map, fluorescence in situ hybridization (FISH), chromosome 1p, prophase FISH ordering system, tumor suppressor gene, stretched DNA | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | departmental bulletin paper | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | AM | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||
| 出版者 名前 | ||||||||||
| 出版者 | 近畿大学医学会 | |||||||||
| 言語 | ja | |||||||||
| bibliographic_information |
ja : 近畿大学医学雑誌 en : Medical Journal of Kinki University 巻 20, 号 1, p. 1-13, 発行日 1995-06-25 |
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| ISSN | ||||||||||
| 収録物識別子タイプ | PISSN | |||||||||
| 収録物識別子 | 03858367 | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | Based on observations of chromosomal aberration, genes that are associated with several types of human tumors (leukemia, neuroblastoma, melanoma, or cancers of colon, stomach and breast, etc.) are located on the short arm of chromosome 1. A high-resolution cytogenetic map of the short arm of human chromosome 1 with newly isolated 411 cosmid markers was constructed by fluorescence in situ hybridization (FISH). These markers were scattered throughout chromosome 1p, but they were preferentially concentrated on the R-band dominant regions such as 1p36, 1p34, 1p32, 1p22, and 1p13, especially on the T-band region (1p36-p34). Among these markers, 197 were localized on chromosome band 1p36, a region frequently deleted in neuroblastoma and malignant melanoma. Of these, 18 were precisely ordered on 1p36.1 by multi-color prophase FISH ordering system and stretched DNA FISH as follows ; 1cen-(1p36.1)-652-176-74-241-561-190-199-451-665-631-614-568-586-226-1-11-41-163-1pter. This high-resolution map of chromosome 1p can provide useful information and landmarks for the human genome project and expedite the identification of breakpoints and/or tumor suppressor gene(s) associated with several types of malignant tumors that frequently exhibit chromosomal aberrations or deletions of chromosome 1p. | |||||||||
| 言語 | en | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | 本文データはCiNiiから複製したものである。 | |||||||||
| 言語 | ja | |||||||||
