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気管支喘息発作時の換気・血流調節と自律神経の関与：気道攣縮時および実験的低酸素状態時の肺循環調節について
https://kindai.repo.nii.ac.jp/records/2001784
https://kindai.repo.nii.ac.jp/records/20017847d54dec2-15b5-42e4-ba44-76047c03e3e5
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AN00063584-19940625-0269.pdf
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| Item type | ☆紀要論文 / Departmental Bulletin Paper(1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2024-09-04 | |||||||||
| タイトル | ||||||||||
| タイトル | 気管支喘息発作時の換気・血流調節と自律神経の関与：気道攣縮時および実験的低酸素状態時の肺循環調節について | |||||||||
| 言語 | ja | |||||||||
| タイトル | ||||||||||
| タイトル | Roles of cholinergic nerve on regulation of ventilation and perfusion in bronchial asthma attack : Regulation of pulmonary circulation in bronchospasm and experimental hypoxia | |||||||||
| 言語 | en | |||||||||
| 著者 |
波津, 龍平
× 波津, 龍平
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| 言語 | ||||||||||
| 言語 | jpn | |||||||||
| キーワード | ||||||||||
| 主題 | bronchospasm, cholinergic nerve, hypoxic pulmonary vasoconstriction, histamine, atro pine, hexamethonium, tetrodotoxin | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | departmental bulletin paper | |||||||||
| 版 | ||||||||||
| 出版タイプ | AM | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||
| 出版者 名前 | ||||||||||
| 出版者 | 近畿大学医学会 | |||||||||
| 言語 | ja | |||||||||
| 書誌情報 |
ja : 近畿大学医学雑誌 en : Medical Journal of Kinki University 巻 19, 号 2, p. 269-286, 発行日 1994-06-25 |
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| ISSN | ||||||||||
| 収録物識別子タイプ | PISSN | |||||||||
| 収録物識別子 | 03858367 | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | Hypoxic pulmonary vasoconstriction (HPV) plays an important role in regulating ventilation-perfusion relationship. In asthma attack, chemical mediators and cholinergic activity may modulate HPV. To determine the roles of cholinergic control on bronchial tone and pulmonary circulation, isolated and perfused cat lungs were used and bronchospasm was induced by the intra-tracheal injection of histamine. Agents which may block cholinergic activities, i.e., atropine, hexamethonium (C_6) and tetrodotoxine (TTX) were administered into the perfusate and the effects of these blockades on histamine induced bronchospasm and HPV were examined. Thirty-three cat lungs were perfused with diluted autologous blood at a constant flow rate. Normoxic gas was used to ventilate the lungs at a tidal volume of 15 ml/kg+5 ml. The changes of P_<PA>, P_<LA>, pulmonary venular pressure (P_<venule>) and airway pressure (P_<Aw>) were monitorad. The lung resistance (R1) and dynamic compliance (Cdyn) were calculated. After measuring the airway and pulmonary circulation parameters in control normoxia and hypoxia, each cholinergic blockade was administered into the perfusate during normoxia followed by hypoxic challenge. Thereafter, histamine was injected into the trachea during the third normoxia to induce bronchospasm. The lung was put into hypoxia again and the effect of each cholinergic blockade on HPV during histamine induced bronchospasm was observed. Atropine (0.5 mg/kg) significantly (p<0.05) decreased P_<AW>, P_<PA> and P_<venule> in control normoxia. C_6 (5 mg, 10 mg/kg) significantly (p<0.05) decreased P_<PA> while TTX did not change P_<PA>, P_<AW> and P_<venule> in control normoxia. Bronchospasm induced by histamine was attenuated only by atropine (1 mg/kg) (p<0.1). Histamine had a greater effect on Cdyn than on R1. Atropine, C_6 and TTX had no effect on HPV alone, but atropine, C_6 and TTX significantly inhibited HPV after histamine-induced bronchospasm (p<0.05). It was concluded that cholinergic nerve partly plays the role in maintaining basal tone (normoxia, without bronchospasm) of the airway and pulmonary blood vessel. Although cholinergic nerve does not play an important role in maintaining vascular tone in HPV alone, it plays the role in HPV after histamine-induced bronchospasm. | |||||||||
| 言語 | en | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | 本文データはCiNiiから複製したものである。 | |||||||||
| 言語 | ja | |||||||||
