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β遮断剤による内因性ANP分泌亢進とその降圧に対する役割
https://kindai.repo.nii.ac.jp/records/2001663
https://kindai.repo.nii.ac.jp/records/2001663dd74affa-84dc-4b9a-a883-5b97379b8107
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AN00063584-19940925-0389.pdf
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| Item type | ☆紀要論文 / Departmental Bulletin Paper(1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2024-08-01 | |||||||||
| タイトル | ||||||||||
| タイトル | β遮断剤による内因性ANP分泌亢進とその降圧に対する役割 | |||||||||
| 言語 | ja | |||||||||
| タイトル | ||||||||||
| タイトル | Influence of β-adrenergic receptor blocking agents on hemodynamics and atrial natriuretic peptide in essential hypertension | |||||||||
| 言語 | en | |||||||||
| 著者 |
永田, 就三
× 永田, 就三
|
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| 言語 | ||||||||||
| 言語 | jpn | |||||||||
| キーワード | ||||||||||
| 主題 | ANP, β-blocker, hypertension, hemodynamics | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | departmental bulletin paper | |||||||||
| 版 | ||||||||||
| 出版タイプ | AM | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||
| 出版者 名前 | ||||||||||
| 出版者 | 近畿大学医学会 | |||||||||
| 言語 | ja | |||||||||
| 書誌情報 |
ja : 近畿大学医学雑誌 en : Medical Journal of Kinki University 巻 19, 号 3, p. 389-402, 発行日 1994-09-25 |
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| ISSN | ||||||||||
| 収録物識別子タイプ | PISSN | |||||||||
| 収録物識別子 | 03858367 | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | The present study investigated the role of atrial natriuretic peptide (ANP) in the mechanism of anti-hypertensive effects of β-blockers in patients with essential hypertension. Propranolol and carteolol were used as β-blockers without and with intrinsic sympathominetic activity (ISA). The drugs were administered for 12 weeks in 17 patients. Cardiac output was measured by the dye dilution method. After administration of propranolol, blood pressure, heart rate and cardiac index were significantly reduced (p<0.05, p<0.001 and p<0.01, respectively), and ANP was significantly increased (p<0.01). A significant negative correlation was observed between percent changes in systolic blood pressure and those in ANP (r=-0.594, p<0.05), whereas no correlation was found between percent changes in systolic blood pressure and those in the cardiac index. The administration of carteolol significantly reduced blood pressure (p<0.05), without affecting heart rate or cardiac index. Carteolol significantly increased ANP, daily urinary output and creatinine clearances (p<0.05, p<0.05 and p<0.05, respectively). These increases were observed only in the responder group in which carteolol reduced systolic blood pressure by 10 mmHg or more. A positive correlation was noted between ANP and daily urinary output (r=0.756, p<0.05). These results indicate that administration of propranolol or carteolol stimulate intrinsic ANP secretion regardless of the presence or absence of reduced cardiac function. In conclusion, the anti-hypertensive mechanism of these β-blockers may partially involve depressor diuretic action due to ANP. | |||||||||
| 言語 | en | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | 本文データはCiNiiから複製したものである。 | |||||||||
| 言語 | ja | |||||||||
