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Effects of Isoteoline on the blood pressure and renin-angiotensin system in spontaneously hypertensive rats
https://kindai.repo.nii.ac.jp/records/2001641
https://kindai.repo.nii.ac.jp/records/2001641bc2ab3a2-1683-43c3-9f72-078d7a2c1498
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AN00063584-19941230-0067.pdf
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| Item type | ☆紀要論文 / Departmental Bulletin Paper(1) | |||||||||||||||
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| 公開日 | 2024-07-26 | |||||||||||||||
| タイトル | ||||||||||||||||
| タイトル | Effects of Isoteoline on the blood pressure and renin-angiotensin system in spontaneously hypertensive rats | |||||||||||||||
| 言語 | en | |||||||||||||||
| 著者 |
Markov, Marko
× Markov, Marko
× Higashino, Hideaki
× Suzuki, Aritomo
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| 言語 | ||||||||||||||||
| 言語 | eng | |||||||||||||||
| キーワード | ||||||||||||||||
| 主題 | Isoteoline (IST), blood pressure, renin-angiotensin-aldosterone system (RAAS), SHR | |||||||||||||||
| 資源タイプ | ||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||
| 資源タイプ | departmental bulletin paper | |||||||||||||||
| 版 | ||||||||||||||||
| 出版タイプ | AM | |||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||||
| 出版者 名前 | ||||||||||||||||
| 出版者 | 近畿大学医学会 | |||||||||||||||
| 言語 | ja | |||||||||||||||
| 書誌情報 |
ja : 近畿大学医学雑誌 en : Medical Journal of Kinki University 巻 19, 号 4補冊, p. 67-72, 発行日 1994-12-30 |
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| ISSN | ||||||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||||||
| 収録物識別子 | 03858367 | |||||||||||||||
| 内容記述 | ||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||
| 内容記述 | The effects of Isoteoline (IST), a new tetrahydroaporphine derivative, on the blood pressure and renin-angiotensin-aldosterone system (RAAS) in spontaneously hypertensive rats (SHR) were studied. The experiments were performed with adult (8 months of age) male SHR of the Okamato-Aoki strain, generation F^<26>-F^<37> weighing 250±10g. Systolic blood pressure was measured indirectly in conscious restrained rats by tail-cuff plethysmography with sphygmomanometer. Plasma renin activity, angiotensin II and aldosterone plasma levels were determined by radio-immunoassay. The angiotensin converting enzyme (ACE) activity in vivo and in vitro was estimated by a modified fluorometric assay, while changes in the electrolyte levels in plasma (Na^+, K^+ and Cl^-) were determined by flame photometry. It was established that IST administered in doses of 1 and 5 mg/kg orally and intraperitoneally after single (6 days) and long-term (14 days 3 times daily) treatment decreased the systolic blood pressure and levels of the components of RAAS. The results suggest that the effects of IST on SHR was most probably realized through an influence on the adrenergic and dopaminergic mediatory systems. | |||||||||||||||
| 言語 | en | |||||||||||||||
| 内容記述 | ||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||
| 内容記述 | 本文データはCiNiiから複製したものである。 | |||||||||||||||
| 言語 | ja | |||||||||||||||
