{"created":"2024-07-26T02:23:12.403326+00:00","id":2001639,"links":{},"metadata":{"_buckets":{"deposit":"bf57ac4d-5abe-4180-958e-ca6cbb630dbc"},"_deposit":{"created_by":42,"id":"2001639","owners":[42],"pid":{"revision_id":0,"type":"depid","value":"2001639"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:02001639","sets":["14:923:1477:1721803201891"]},"author_link":[],"item_2_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1994-12-30","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4補冊","bibliographicPageEnd":"60","bibliographicPageStart":"57","bibliographicVolumeNumber":"19","bibliographic_titles":[{"bibliographic_title":"近畿大学医学雑誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Medical Journal of Kinki University","bibliographic_titleLang":"en"}]}]},"item_2_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Using antisense oligodeoxynucleotides (ODNs), we investigated whether c-myc protein production by angiotensin II (A-II) was involved in hypertrophy of vascular smooth muscle cells (VSMCs). We designed antisense ONDs specific for c-myc mRNA. The cultured VSMCs were isolated from Sprague-Dawley rats (male 7-8 weeks) by the explant method. The cells were stimulated by 10^<-5> M A-II with or without antisense ODNs or sense ODNs. The growth response to A-II was assessed by the uptake of [^3H]thymidine (Td) or [^3H]leucine. A-II increased [^3H]Td uptake into VSMCs while antisense ODNs for c-myc mRNA specifically inhibited uptake, in a concentration-dependent manner. More than 5pM antisense ODNs showed significant effects on the inhibition and the maximal inhibitory effect was 75% in 500pM concentration. However, sense ODNs did not demonstrate the same results. Similarly, c-myc antisense ODNs decreased [^3H]leucine uptake into VSMCs by A-II stimulation. Our results suggest that the c-myc gene product in VSMCs by A-II is involved in the hypertrophic effects induced by A-II.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"本文データはCiNiiから複製したものである。","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_2_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学医学会","subitem_publisher_language":"ja"}]},"item_2_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03858367","subitem_source_identifier_type":"PISSN"}]},"item_2_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kinki University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"鴨井, 公司","creatorNameLang":"ja"},{"creatorName":"Kamoi, Kouji","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kinki University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"堀内, 正嗣","creatorNameLang":"ja"},{"creatorName":"Horiuchi, Masatsugu","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kinki University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"浜, 純吉","creatorNameLang":"ja"},{"creatorName":"Hama, Junkichi","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kinki University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"竹中, 俊彦","creatorNameLang":"ja"},{"creatorName":"Takenaka, Toshihiko","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kinki University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"木野, 博文","creatorNameLang":"ja"},{"creatorName":"Kino, Hirofumi","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kinki University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"杉村, 圭一","creatorNameLang":"ja"},{"creatorName":"Sugimura, Keiichi","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kinki University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"島田, 誠二郎","creatorNameLang":"ja"},{"creatorName":"Shimada, Seijiro","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kinki University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"甲斐, 達也","creatorNameLang":"ja"},{"creatorName":"Kai, Tatsuya","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kinki University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"永田, 就三","creatorNameLang":"ja"},{"creatorName":"Nagata, Shuzo","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kinki University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"近藤, 宏和","creatorNameLang":"ja"},{"creatorName":"Kondo, Hirokazu","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kinki University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"山本, 義浩","creatorNameLang":"ja"},{"creatorName":"Yamamoto, Yoshihiro","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kinki University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"香取, 瞭","creatorNameLang":"ja"},{"creatorName":"Katori, Ryo","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"AN00063584-19941230-0057.pdf","format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://kindai.repo.nii.ac.jp/record/2001639/files/AN00063584-19941230-0057.pdf"},"version_id":"5a4c0fdd-7e09-48ce-9bf1-2b8445a18066"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"angiotensin II","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"vascular smooth muscle cell","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"c-myc","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"antisense oligodeoxynucleotides","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"アンジオテンシンIIの血管平滑筋細胞肥大作用におけるc-mycの関与について","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"アンジオテンシンIIの血管平滑筋細胞肥大作用におけるc-mycの関与について","subitem_title_language":"ja"},{"subitem_title":"Role of c-myc in vascular smooth muscle cell hypertrophy under angiotensin II stimulation","subitem_title_language":"en"}]},"item_type_id":"2","owner":"42","path":["1721803201891"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-07-26"},"publish_date":"2024-07-26","publish_status":"0","recid":"2001639","relation_version_is_last":true,"title":["アンジオテンシンIIの血管平滑筋細胞肥大作用におけるc-mycの関与について"],"weko_creator_id":"42","weko_shared_id":-1},"updated":"2024-09-02T02:29:18.184537+00:00"}