| アイテムタイプ |
☆紀要論文 / Departmental Bulletin Paper(1) |
| 公開日 |
2024-07-26 |
| タイトル |
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タイトル |
SHRSP脳におけるスーパーオキサイドジスムターゼ(SOD)活性の変化 |
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言語 |
ja |
| タイトル |
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タイトル |
Change in superoxide dismutase activity in SHRSP brain |
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言語 |
en |
| 著者 |
西田, 升三
木本, さおり
船阪, 有彦
中野, 貴之
寺本, 和弘
小橋, 和雄
楠, 威志
戸村, 隆訓
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| 言語 |
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言語 |
jpn |
| キーワード |
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主題 |
SOD, SHRSP, brain, vulnerability of nerve cell |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
departmental bulletin paper |
| 版 |
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出版タイプ |
AM |
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出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 出版者 名前 |
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出版者 |
近畿大学医学会 |
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言語 |
ja |
| 書誌情報 |
ja : 近畿大学医学雑誌
en : Medical Journal of Kinki University
巻 19,
号 4補冊,
p. 47-49,
発行日 1994-12-30
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| ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
03858367 |
| 内容記述 |
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内容記述タイプ |
Abstract |
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内容記述 |
Clinical and experimental evidence demonstrates that nerve cells of spontaneously hypertensive rats (SHR) or stroke-prone spontaneously hypertensive rats (SHRSP) are more sensitive to ischemic injury that those of Wistar Kyoto rats (WKY), and that lipidperoxide increases significantly in the SHRSP brain with aging. To elucidate the vulnerability of SHRSP nerve cells, the activity of SOD, the enzyme that protects cells against reactive free radicals by catalyzing dismutation, was examined in the brain tissues (cerebral cortex and hippocampus) of SHRSP in comparison with that of WKY. There was no significant difference in cerebral cortices between 15-week-old SHRSP and WKY. However, at 31 week old close to the onset of stroke, overall SOD activities in the cerebral cortex of SHRSP were significantly lower than those in WKY. Moreover, SOD activity in the hippocampus, the region of selective neuronal vulnerability, was lower than that in the cerebral cortex of either SHRSP or WKY. These results indicate that low SOD activity in SHRSP is closely related to the vulnerability of SHRSP nerve cells and the increased lipidperoxide of SHRSP brain tissue. |
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言語 |
en |
| 内容記述 |
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内容記述タイプ |
Other |
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内容記述 |
本文データはCiNiiから複製したものである。 |
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言語 |
ja |
AN00063584-19941230-0047.pdf
