| アイテムタイプ |
☆紀要論文 / Departmental Bulletin Paper(1) |
| 公開日 |
2024-07-26 |
| タイトル |
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タイトル |
WKYならびにSHRSPの摘出腎動脈におけるアセチルコリンによる内皮細胞依存性収縮反応 |
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言語 |
ja |
| タイトル |
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|
タイトル |
Endothelium-dependent contractions induced by acetylcholine in renal arteries isolated from WKY and SHRSP |
|
言語 |
en |
| 著者 |
西村, 芳卓
鈴木, 有朋
宮武, 里江
中井, 義裕
河, 東成
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| 言語 |
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言語 |
jpn |
| キーワード |
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主題 |
WKY, SHRSP, renal artery, acetylcholine, endothelium-dependent contraction |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
departmental bulletin paper |
| 版 |
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|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 出版者 名前 |
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出版者 |
近畿大学医学会 |
|
言語 |
ja |
| 書誌情報 |
ja : 近畿大学医学雑誌
en : Medical Journal of Kinki University
巻 19,
号 4補冊,
p. 35-38,
発行日 1994-12-30
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| ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
03858367 |
| 内容記述 |
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内容記述タイプ |
Abstract |
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内容記述 |
We examined the contractile responses to acetylcholine (ACh) in isolated renal artery rings obtained from WKY and SHRSP at 3 and 6 months of age. ACh caused a transient contraction in endothelium-intact renal arteries from WKY and SHRSP. ACh-induced contraction was abolished by removal of the endothelium, and was augmented by pretreatment with N^G-nitro-L-arginine (NOARG) in both groups. Indomethacin completely inhibited ACh-induced contraction in NOARG-treated arteries of WKY and SHRSP. Contraction induced by ACh was significantly smaller in SHRSP at 3 and 6 months of age than in age-matched WKY. ACh-induced endothelium-dependent relaxation in renal arteries precontracted with phenylephrine was decreased in SHRSP at 3 and 6 months of age when compared to age-matched WKY. Relaxation induced by ACh was inhibited by NOARG in both groups. These results suggest that ACh produces both contractile responses mediated by cyclooxygenase products and relaxation responses mediated by nitric oxide in an endothelium-dependent manner, and that these responses were impaired in SHRSP. |
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言語 |
en |
| 内容記述 |
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内容記述タイプ |
Other |
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内容記述 |
本文データはCiNiiから複製したものである。 |
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言語 |
ja |
AN00063584-19941230-0035.pdf
