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延長仮骨における骨基質蛋白の遺伝子発現
https://kindai.repo.nii.ac.jp/records/2001607
https://kindai.repo.nii.ac.jp/records/2001607482a2f46-6cf8-43ba-a966-553587cb4239
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AN00063584-19941225-0553.pdf
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| アイテムタイプ | ☆紀要論文 / Departmental Bulletin Paper(1) | |||||||||
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| 公開日 | 2024-07-19 | |||||||||
| タイトル | ||||||||||
| タイトル | 延長仮骨における骨基質蛋白の遺伝子発現 | |||||||||
| 言語 | ja | |||||||||
| タイトル | ||||||||||
| タイトル | Gene expression of bone matrix proteins in the lengthened callus | |||||||||
| 言語 | en | |||||||||
| 著者 |
戸谷, 由樹
× 戸谷, 由樹
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| 言語 | ||||||||||
| 言語 | jpn | |||||||||
| キーワード | ||||||||||
| 主題 | lengthened callus, oncogene, c-fos, osteonectin, osteocalcin, collagen type I, II, III | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | departmental bulletin paper | |||||||||
| 版 | ||||||||||
| 出版タイプ | AM | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||
| 出版者 名前 | ||||||||||
| 出版者 | 近畿大学医学会 | |||||||||
| 言語 | ja | |||||||||
| 書誌情報 |
ja : 近畿大学医学雑誌 en : Medical Journal of Kinki University 巻 19, 号 4, p. 553-572, 発行日 1994-12-25 |
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| ISSN | ||||||||||
| 収録物識別子タイプ | PISSN | |||||||||
| 収録物識別子 | 03858367 | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | Gene expression of c-fos, osteonectin, osteocalcin and type I , II and III collagens were studied in the lengthened callus made in rabbit tibia and rat femur. The lengthened callus was separated in to two parts histologically ; peripheral subperiosteal callus and central medullary callus. Northern blot analysis revealed that c-fos mRNA was expressed in the peripheral subperiosteal callus earlier and more markedly than those in the central medullary callus, although expression in the medullary callus continued until 40 days after lengthening was completed. In situ hybridization technique revealed that the mRNA of osteonectin was expressed massively in the trabecular portion of the peripheral callus earlier, and expressed in those of central medullary callus later, but was not expressed in the cartilaginous tissue. Immunohistochemically, fos protein was first observed in the large osteoblasts on the matured bony trabeculae in the peripheral periosteal callus, and later, in the osteoblastic cells in primitive bones in the mesenchymal cell layer of the central medullary callus. Osteocalcin was positively stained in the bony matrix and osteocytes were found in the peripheral subperiosteal callus, while osteoblasts were found in the primitive trabeculae in the central medullary callus. Type I collagen appeared in the osteoblasts of the primitive bone trabeculae. Type II collagen was indicated in the perilacunar area of matured cartilaginous tissue. Type III collagen appeared in the immature mesenchymal cells adjacent to the trabecular layer in the eariest stage. These results suggest that gene expression of fos and type III collagen initiated the differentiation of mesenchymal cells in to osteoblasts and chondroblasts, while gene expression of osteonectin and type I collagen stimulated massive primitive bone matrix formation, and gene expression of osteocalcin regulated the calcification and maturation of the bone matrix. | |||||||||
| 言語 | en | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | 本文データはCiNiiから複製したものである。 | |||||||||
| 言語 | ja | |||||||||
