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成人T細胞白血病由来因子(ATL-derived factor : ADF)の心筋虚血再灌流不整脈におよぼす影響についての実験的検討
https://kindai.repo.nii.ac.jp/records/2001573
https://kindai.repo.nii.ac.jp/records/200157367b9ae93-499c-4e15-a3a6-2ab99e8af957
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AN00063584-19951225-0293.pdf
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| Item type | ☆紀要論文 / Departmental Bulletin Paper(1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2024-07-12 | |||||||||
| タイトル | ||||||||||
| タイトル | 成人T細胞白血病由来因子(ATL-derived factor : ADF)の心筋虚血再灌流不整脈におよぼす影響についての実験的検討 | |||||||||
| 言語 | ja | |||||||||
| タイトル | ||||||||||
| タイトル | Effects of ADF (ATL-derived factor) on reperfusion-induced arrhythmias in the isolated perfused rat heart | |||||||||
| 言語 | en | |||||||||
| 著者 |
楳田, 高士
× 楳田, 高士
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| 言語 | ||||||||||
| 言語 | jpn | |||||||||
| キーワード | ||||||||||
| 主題 | ADF, SOD, Reperfusion, Arrhythmia, Free redical | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | departmental bulletin paper | |||||||||
| 版 | ||||||||||
| 出版タイプ | AM | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||
| 出版者 名前 | ||||||||||
| 出版者 | 近畿大学医学会 | |||||||||
| 言語 | ja | |||||||||
| 書誌情報 |
ja : 近畿大学医学雑誌 en : Medical Journal of Kinki University 巻 20, 号 2, p. 293-307, 発行日 1995-12-25 |
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| ISSN | ||||||||||
| 収録物識別子タイプ | PISSN | |||||||||
| 収録物識別子 | 03858367 | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | Adult T cell leukemia-derived factor (ADF) has been reported to be a cytokine which acts as a defensive factor against oxidative stress. The present study was designed first to assess whether ADF has an antiarrhythmic effect against reperfusion-induced arrhythmias (Experiment 1), second to compare the efficiency of the antiarrhythmic property of ADF with SOD (Experiment 2), and third to examine the effects of the combined administration of ADF and SOD on reperfusion-induced arrhythmias (Experiment 3). The isolated male Wister rat heart (n=364) was subjected to regional ischemia (occlusion of left anterior descending coronary artery for 11 minutes) and reperfusion (3 minutes). Experiment 1 : ADF reduced the duration of ventricular fibrillation (VF) and the incidence of sustained VF, describing a mirrored bell-shaped curve with a dose-dependent response characteristic. The effective dose of ADF (0.25～1.0 mg/l) reduced the duration of VF and incidence of sustained VF from the control values of 160.8±6.8 sec (mean±SEM) and 92.9% to 83.3±20.2 sec～114.7±19.5 sec and 35.7%～57.1%, respectively (P<0.05). Experiment 2 : SOD decreased the duration of VF and the incidence of sustained VF. The dose-response curve exhibited a mirrored bell-shaped profile. The effective dose of SOD (7.5×10^3～1×10^5 U/l) reduced the duration of VF from the control values of 163.5±5.4 sec to 70.8±20.5 sec～113.1±19.9 sec and the incidence of sustained VF from 92.9% to 28.6%～57.1%, respectively (P<0.05). Experiment 3 : The optimal combination doses of ADF and SOD (0.5 mg/l and 5×10^3 U/l, respectively) reduced the duration of VF and the incidence of sustained VF significantly in comparison with those observed with 0.5 mg/l of ADF alone. In conclusion, ADF has an inhibitory effect on the reperfusion-induced arrhythmias and the attenuation of the reperfusion-induced arrhythmias by ADF may arise from the ability of ADF to scavenge hydrogen peroxide. ADF may be clinically useful in the therapy of reperfusion-induced arrhythmias. | |||||||||
| 言語 | en | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | 本文データはCiNiiから複製したものである。 | |||||||||
| 言語 | ja | |||||||||
