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閉塞性黄疸ラットにおけるポリエチレングリコール結合ビリルビンオキシターゼによる減黄効果
https://kindai.repo.nii.ac.jp/records/2001565
https://kindai.repo.nii.ac.jp/records/2001565f5dc28f4-b6bb-44f8-90a8-546146179ea9
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AN00063584-19951225-0201.pdf
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| Item type | ☆紀要論文 / Departmental Bulletin Paper(1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2024-07-12 | |||||||||
| タイトル | ||||||||||
| タイトル | 閉塞性黄疸ラットにおけるポリエチレングリコール結合ビリルビンオキシターゼによる減黄効果 | |||||||||
| 言語 | ja | |||||||||
| タイトル | ||||||||||
| タイトル | Metabolic effects of bilirubin removal by polyethylene glycol-bound bilirubin oxidase in icteric rats | |||||||||
| 言語 | en | |||||||||
| 著者 |
宮脇, 正三
× 宮脇, 正三
|
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| 言語 | ||||||||||
| 言語 | jpn | |||||||||
| キーワード | ||||||||||
| 主題 | bilirubin, obstructive jaundice, polyethylene glycol, birirubin oxidase | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | departmental bulletin paper | |||||||||
| 版 | ||||||||||
| 出版タイプ | AM | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||
| 出版者 名前 | ||||||||||
| 出版者 | 近畿大学医学会 | |||||||||
| 言語 | ja | |||||||||
| 書誌情報 |
ja : 近畿大学医学雑誌 en : Medical Journal of Kinki University 巻 20, 号 2, p. 201-210, 発行日 1995-12-25 |
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| ISSN | ||||||||||
| 収録物識別子タイプ | PISSN | |||||||||
| 収録物識別子 | 03858367 | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | In hepatobiliary diseases accompanied by jaundice, it is not known to what extent the increased bilirubin causes hepatocyte dysfunction. In order to determine whether bilirubin is responsible for the dysfunction, the polyethylene glycol conjugate of bilirubin oxidase (PEG-BOX), which has a long plasma half-life, was administered to rats with obstructive jaundice (PEG-BOX group), and compared with the control group which was administered polyethylene glycol 5000 alone after bile duct ligation. In the PEG-BOX group, both serum and tissue levels of bilirubin were markedly decreased below those in the control group. The serum level of bile acid in the PEG-BOX group was lower, being associated with its increased urinary excretion than in the control group. No significant difference was observed in hepatic microsomal 7α-hydroxylase activity between the two groups. The serum taurine-conjugated bile acid fraction was higher in the PEG-BOX group than that in the control group. Serum levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, albumin and total protein were all similar between the two groups. Although the hepatic ATP level and the energy charge of the adenylate pool decreased 3 and 7 days after bile duct ligation, their preservation was higher in the PEG-BOX group than in the control group. In conclusion, lowering of serum and hepatic bilirubin in the bile duct-ligated rats by an application of PEG-BOX resulted in a decrease in the serum bile acid level and increase of urinary excretion of bile acid and thus appears to help retain the liver ATP. | |||||||||
| 言語 | en | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | 本文データはCiNiiから複製したものである。 | |||||||||
| 言語 | ja | |||||||||
