{"created":"2024-06-26T05:56:28.195666+00:00","id":2001459,"links":{},"metadata":{"_buckets":{"deposit":"ba653793-2556-4b70-9805-509d2661d7bd"},"_deposit":{"created_by":42,"id":"2001459","owners":[42],"pid":{"revision_id":0,"type":"depid","value":"2001459"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:02001459","sets":["14:923:1477:1719297476443"]},"author_link":[],"item_2_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1995-12-30","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2補冊","bibliographicPageEnd":"23","bibliographicPageStart":"21","bibliographicVolumeNumber":"20","bibliographic_titles":[{"bibliographic_title":"近畿大学医学雑誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Medical Journal of Kinki University","bibliographic_titleLang":"en"}]}]},"item_2_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"SHRSPを用いて，選択的α_1-刺激薬である塩酸メトキサミンの末梢血行動態に対する影響を放射性マイクロスフェアー法により観察した．心係数，局所血流量の計測は，2種類のマイクロスフェアー(^<57>Co，^<113>Sn : φ16.5±0.1μm)を一尾のラットについて生理食塩水投与40秒後と薬物投与40秒後に，右頚動脈カテーテルを通じて左心室内に注入して行った．その結果，平均動脈圧はメトキサミン投与後，平均動脈圧の38%の上昇に対して心拍数は28%低下した．したがって，このような高度な血圧上昇に対しては圧受容体反射機構はSHRSPでも比較的正常に作動するものと思われた．また，心係数は有意に低下し，総末梢血管抵抗係数は有意に上昇した．皮膚の局所血流量は末梢血管抵抗の上昇により有意な低下を示し，筋肉の局所血流量は57%低下して筋末梢血管抵抗は約4倍上昇した．脳，心臓では，末梢血管抵抗は変化しなかったものの局所血流量は約30%増加した．心係数の有意な低下に対して脳，心臓の重要臓器での血管抵抗には変化がなく，それぞれの局所血流量が増加傾向を示したことから，脳，心臓の心拍出量分配率が増加したことが示唆された．","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"本文データはCiNiiから複製したものである。","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_2_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学医学会","subitem_publisher_language":"ja"}]},"item_2_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03858367","subitem_source_identifier_type":"PISSN"}]},"item_2_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kinki University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"吾孫子, 邦生","creatorNameLang":"ja"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kinki University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"東野, 英明","creatorNameLang":"ja"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kinki University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"鈴木, 有朋","creatorNameLang":"ja"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kinki University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"菱田, 守彦","creatorNameLang":"ja"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"AN00063584-19951230-0021.pdf","format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://kindai.repo.nii.ac.jp/record/2001459/files/AN00063584-19951230-0021.pdf"},"version_id":"e46475b7-c657-4a06-aa8c-c2391c6c66c3"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"メトキサミン","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"α_1-作動薬","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"SHRSP","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"マイクロスフェアー法","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"局所血流量","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"α_1-刺激薬メトキサミンが意識下SHRSPの血行動態に与えた影響","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"α_1-刺激薬メトキサミンが意識下SHRSPの血行動態に与えた影響","subitem_title_language":"ja"}]},"item_type_id":"2","owner":"42","path":["1719297476443"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-06-26"},"publish_date":"2024-06-26","publish_status":"0","recid":"2001459","relation_version_is_last":true,"title":["α_1-刺激薬メトキサミンが意識下SHRSPの血行動態に与えた影響"],"weko_creator_id":"42","weko_shared_id":-1},"updated":"2024-07-19T07:14:51.683083+00:00"}