{"created":"2024-06-26T05:56:18.690446+00:00","id":2001456,"links":{},"metadata":{"_buckets":{"deposit":"f9803ef3-caa8-4ae9-8b93-dc89f09f258b"},"_deposit":{"created_by":42,"id":"2001456","owners":[42],"pid":{"revision_id":0,"type":"depid","value":"2001456"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:02001456","sets":["14:923:1477:1719297476443"]},"author_link":[],"control_number":"2001456","item_2_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1995-12-30","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2補冊","bibliographicPageEnd":"11","bibliographicPageStart":"9","bibliographicVolumeNumber":"20","bibliographic_titles":[{"bibliographic_title":"近畿大学医学雑誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Medical Journal of Kinki University","bibliographic_titleLang":"en"}]}]},"item_2_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"脳卒中の発症におよぼす血液線溶系の変化を検討するために，脳卒中易発症高血圧自然発症ラット(SHRSP)とWister Kyoto rat (WKY)の脳，腎臓および肝臓組織抽出液中のplasminogen activator (PA)活性とPA inhibitor (PAI)活性を測定した．SHRSPの脳と腎組織中のPA活性は，それぞれWKYの1.5倍と2.9倍であったが，肝臓組織中におけるSHRSPのPA活性はWKYの1/1.5であった．また，脳と腎臓組織中のPAI活性はWKYの方がSHRSPよりもそれぞれ1.2倍強かった．脳組織中に認められたPA活性はtissue-type PA (t-PA)由来であり，腎臓と肝臓組織中に認められたPA活性はt-PAとurokinase-type PA (u-PA)由来であった．さらに，脳および腎臓組織中のPAI活性はPAI-1に由来し，肝臓組織中の線溶阻害活性はα_2-PIであることが明かになった．WKYよりもSHRSPの脳組織中において線溶系の活性化が強く，これがSHRSPの脳卒中易発症に関与するものと考えられた．","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"本文データはCiNiiから複製したものである。","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_2_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学医学会","subitem_publisher_language":"ja"}]},"item_2_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03858367","subitem_source_identifier_type":"PISSN"}]},"item_2_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kinki University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"上嶋, 繁","creatorNameLang":"ja"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kinki University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"岡田, 清孝","creatorNameLang":"ja"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kinki University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"深尾, 偉晴","creatorNameLang":"ja"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kinki University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"高石, 知明","creatorNameLang":"ja"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kinki University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"松尾, 理","creatorNameLang":"ja"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"AN00063584-19951230-0009.pdf","format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://kindai.repo.nii.ac.jp/record/2001456/files/AN00063584-19951230-0009.pdf"},"version_id":"42a52cc5-4f61-4f4c-ba3f-9d3b8709afc8"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"SHRSP","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"WKY","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"fibrinolysis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"plasminogen activator","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"plasminogen activator inhibitor","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"SHRSPの脳，腎臓および肝臓組織中の線溶系因子","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"SHRSPの脳，腎臓および肝臓組織中の線溶系因子","subitem_title_language":"ja"}]},"item_type_id":"2","owner":"42","path":["1719297476443"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-06-26"},"publish_date":"2024-06-26","publish_status":"0","recid":"2001456","relation_version_is_last":true,"title":["SHRSPの脳，腎臓および肝臓組織中の線溶系因子"],"weko_creator_id":"42","weko_shared_id":-1},"updated":"2024-07-19T07:14:55.026503+00:00"}