{"created":"2024-06-10T01:44:04.294409+00:00","id":2001378,"links":{},"metadata":{"_buckets":{"deposit":"9976e349-6cc9-4c88-bbc9-bb959751e1ce"},"_deposit":{"created_by":42,"id":"2001378","owners":[42],"pid":{"revision_id":0,"type":"depid","value":"2001378"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:02001378","sets":["14:923:1477:1717565111739"]},"author_link":[],"control_number":"2001378","item_2_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1996-06-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"11","bibliographicPageStart":"1","bibliographicVolumeNumber":"21","bibliographic_titles":[{"bibliographic_title":"近畿大学医学雑誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Medical Journal of Kinki University","bibliographic_titleLang":"en"}]}]},"item_2_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"小児期の各種腎尿路系疾患患児109例を対象に尿中interleukin (IL)-6，IL-1β，tumor necrosis factor (TNF)-α，とsoluble interleukin (sIL)-2Rを測定し，さらに末梢静脈血単核細胞によるIL-2産生能について検討し，その臨床的意義を研究した．IL-6，IL-1β，TNF-α，sIL-2R，それぞれの尿中値と血清中値の比較では，両者に相関関係を認めず，腎局所での産生の可能性が推察された．尿中IL-6，IL-1β値はメサンギウム増殖性腎炎患者尿で高値を示し，尿中IL-6，IL-1β，TNF-α値とは腎生検組織像の比較では，これらのサイトカインはメサンギウムの増殖性変化と相関を示した．尿中sIL-2R値はminimal change nephrotic syndromeとacute pyelonephritisで尿中総蛋白濃度の増加に伴って高値を示し，尿蛋白排泄との関連性が推測された．末梢静脈血単核細胞のIL-2産生能の亢進はIgA nephropathy患者で観察され，潜在的なT細胞過敏状態が示唆された．","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"本文データはCiNiiから複製したものである。","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_2_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学医学会","subitem_publisher_language":"ja"}]},"item_2_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03858367","subitem_source_identifier_type":"PISSN"}]},"item_2_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kinki University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"道旗, 巌","creatorNameLang":"ja"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"AN00063584-19960625-0001.pdf","format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://kindai.repo.nii.ac.jp/record/2001378/files/AN00063584-19960625-0001.pdf"},"version_id":"e2277f59-f8c3-47bb-b11a-913c9102e5ff"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"interleukin-6 (IL-6)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"interleukin-1β (IL-1β)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"tumor necrosis factor-α (TNF-α)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"soluble interleukin-2 receptor (sIL-2R)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"interleukin-2 (IL-2)","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"各種小児腎疾患における尿中IL-6，IL-1β，TNF-α，sIL-2R値およびIL-2産生能測定の臨床的意義","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"各種小児腎疾患における尿中IL-6，IL-1β，TNF-α，sIL-2R値およびIL-2産生能測定の臨床的意義","subitem_title_language":"ja"}]},"item_type_id":"2","owner":"42","path":["1717565111739"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-06-10"},"publish_date":"2024-06-10","publish_status":"0","recid":"2001378","relation_version_is_last":true,"title":["各種小児腎疾患における尿中IL-6，IL-1β，TNF-α，sIL-2R値およびIL-2産生能測定の臨床的意義"],"weko_creator_id":"42","weko_shared_id":-1},"updated":"2024-07-03T00:13:26.720113+00:00"}