{"created":"2024-05-17T02:16:56.183659+00:00","id":2001270,"links":{},"metadata":{"_buckets":{"deposit":"4c8bc945-9582-4990-8ba3-414c0f1a4218"},"_deposit":{"created_by":42,"id":"2001270","owners":[42],"pid":{"revision_id":0,"type":"depid","value":"2001270"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:02001270","sets":["14:923:1477:1715824167512"]},"author_link":[],"control_number":"2001270","item_2_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1996-12-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"286","bibliographicPageStart":"281","bibliographicVolumeNumber":"21","bibliographic_titles":[{"bibliographic_title":"近畿大学医学雑誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Medical Journal of Kinki University","bibliographic_titleLang":"en"}]}]},"item_2_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"全身性の自己免疫疾患である全身性エリテマトーデス(SLE)と接着分子の関係について，抗体産生における接着分子の役割を検討した．なかでも，intercellular adhesion molecule-1のリガンドであり，最近，マウスで抗DNA抗体産生B細胞亜群の表面マーカーの一つとして報告されているCD43分子について，ヒトのSLEの病態における意義を検討した．CD43分子の発現は抗DNA抗体が高値の症例で，増加していた．また，活動期SLE症例のB細胞のうち，CD5(-)CD43(+)細胞が高率にIgGクラスの抗DNA抗体を産生していた．一方，健常人およびSLE症例の末梢単核細胞のIgGおよびIgM産生量は抗接着分子抗体の添加によって減少した．また，SLE症例の末梢単核細胞のIgGクラスの抗DNA抗体の産生量は抗CD43抗体の添加によって減少した．以上のことからB細胞上のCD43分子は，単なる活性化のマーカーではなく，抗DNA抗体生産に深く関与していると考えられた．","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"本文データはCiNiiから複製したものである。","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_2_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学医学会","subitem_publisher_language":"ja"}]},"item_2_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03858367","subitem_source_identifier_type":"PISSN"}]},"item_2_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kinki University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"大野, 基樹","creatorNameLang":"ja"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kinki University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"船内, 正憲","creatorNameLang":"ja"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"AN00063584-19961225-0281.pdf","format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://kindai.repo.nii.ac.jp/record/2001270/files/AN00063584-19961225-0281.pdf"},"version_id":"baffbeb7-7e2c-45f1-acc4-d29e31a7352e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"systemic lupus erythematosus","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"anti DNA antibody","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"adhesion molecule","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"CD43","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"antibody production","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"全身性エリテマトーデスの抗DNA抗体産生におけるCD43分子の役割","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"全身性エリテマトーデスの抗DNA抗体産生におけるCD43分子の役割","subitem_title_language":"ja"}]},"item_type_id":"2","owner":"42","path":["1715824167512"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-05-17"},"publish_date":"2024-05-17","publish_status":"0","recid":"2001270","relation_version_is_last":true,"title":["全身性エリテマトーデスの抗DNA抗体産生におけるCD43分子の役割"],"weko_creator_id":"42","weko_shared_id":-1},"updated":"2024-07-19T07:14:19.683623+00:00"}