{"created":"2024-04-24T05:32:49.145909+00:00","id":2001135,"links":{},"metadata":{"_buckets":{"deposit":"aaf67b87-d16f-4552-9f3a-3e24711918fb"},"_deposit":{"created_by":42,"id":"2001135","owners":[42],"pid":{"revision_id":0,"type":"depid","value":"2001135"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:02001135","sets":["14:923:1519:1713932063545"]},"author_link":[],"control_number":"2001135","item_30002_bibliographic_information29":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2024-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"6","bibliographicPageStart":"1","bibliographicVolumeNumber":"49","bibliographic_titles":[{"bibliographic_title":"ACTA MEDICA KINDAI UNIVERSITY","bibliographic_titleLang":"en"}]}]},"item_30002_creator2":{"attribute_name":"作成者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Sugimoto, Koji","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Yamada, Takahiro","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Kono, Atsushi","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Im, SungWoon","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Ishii, Kazunari","creatorNameLang":"en"}]}]},"item_30002_description9":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Purpose: Our earlier investigation assessed the correlation between regional accumulations of a tau positron emission tomography (PET) tracer (THK5351) and cognitive dysfunction in the Alzheimer's disease (AD) continuum brain. We reported significant correlations between bilateral parietotemporal and left posterior cingulate/precuneus THK5351 accumulations and Mini-Mental State Examination (MMSE)/Alzheimer Disease Assessment Scale-Cognitive Subtest (ADAS) scores. Herein, we explored the relationship between these variables in non-AD pathologic brains.\n\nMethods: Thirty-one subjects with non-AD pathologic changes (mean age: 64.6 ± 11.3 yrs) underwent three-dimensional MRI, fluoro-2-deoxyglucose (FDG)-(PET), Pittsburgh compound B (PiB)-amyloid PET, and THK5351-tau PET. All subjects completed the MMSE (mean ± SD score: 27.0 ± 4.1), and 20 subjects (mean age: 63.8 ± 11.9 yrs) also completed the ADAS (9.7 ± 9.3). A voxel-wise statistical analysis using statistical parametric mapping determined the correlations between each subject's FDG and THK imaging results and their MMSE and ADAS scores.\n\nResults: The voxel-wise statistical analysis revealed that FDG accumulations in the left temporal cortices were significantly positively correlated with the subjects' MMSE scores and significantly negatively correlated with their ADAS scores. A negative correlation was observed between the subjects' MMSE scores and THK5351 accumulations in the left temporal and medial frontal cortices and the right temporal pole. A positive correlation was observed between the subjects' ADAS scores and THK5351 accumulations in the left temporal cortices and the right anterior temporal lobe.\n\nConclusions: Compared to FDG accumulation, THK5351 accumulations correlated more strongly with neuropsychological test scores in non-AD pathologic brains, likely due to THK5351's affinity for both tau and monoamine oxidase-B. THK5351 measurements may be valuable for clarifying the pathophysiology of non-AD pathologic changes in the brain.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_30002_file35":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"AA0050842X-20240600-0001.pdf","format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://kindai.repo.nii.ac.jp/record/2001135/files/AA0050842X-20240600-0001.pdf"},"version_id":"64544b93-ce3c-4fa2-91ea-c472c4815a65"}]},"item_30002_identifier_registration17":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15100/0002001135","subitem_identifier_reg_type":"JaLC"}]},"item_30002_language12":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_30002_publisher10":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"The Kindai University Medical Association","subitem_publisher_language":"en"}]},"item_30002_resource_type13":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_30002_source_identifier22":{"attribute_name":"収録物識別子","attribute_value_mlt":[{"subitem_source_identifier":"03866092","subitem_source_identifier_type":"PISSN"},{"subitem_source_identifier":"24327166","subitem_source_identifier_type":"EISSN"}]},"item_30002_subject8":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"non-AD pathology","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"tau","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"THK5351","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"PET","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"MMSE","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"ADAS","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_30002_title0":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Correlation between regional cerebral THK5351 accumulations and neuropsychological test scores in brains with non-AD pathologic changes","subitem_title_language":"en"}]},"item_30002_version_type15":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_title":"Correlation between regional cerebral THK5351 accumulations and neuropsychological test scores in brains with non-AD pathologic changes","item_type_id":"40004","owner":"42","path":["1713932063545"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-06-20"},"publish_date":"2024-06-20","publish_status":"0","recid":"2001135","relation_version_is_last":true,"title":["Correlation between regional cerebral THK5351 accumulations and neuropsychological test scores in brains with non-AD pathologic changes"],"weko_creator_id":"42","weko_shared_id":-1},"updated":"2024-06-24T06:10:52.681755+00:00"}