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Correlation between regional cerebral THK5351 accumulations and neuropsychological test scores in brains with non-AD pathologic changes
https://doi.org/10.15100/0002001135
https://doi.org/10.15100/000200113591521bc7-6ac7-4d28-8d7b-f55e723842fe
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AA0050842X-20240600-0001.pdf
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| Item type | 紀要論文 / departmental bulletin paper(1) | |||||||||||||||
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| 公開日 | 2024-06-20 | |||||||||||||||
| タイトル | ||||||||||||||||
| タイトル | Correlation between regional cerebral THK5351 accumulations and neuropsychological test scores in brains with non-AD pathologic changes | |||||||||||||||
| 言語 | en | |||||||||||||||
| 作成者 |
Sugimoto, Koji
× Sugimoto, Koji
× Yamada, Takahiro
× Kono, Atsushi
× Im, SungWoon
× Ishii, Kazunari
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| 言語 | ||||||||||||||||
| 言語 | eng | |||||||||||||||
| キーワード | ||||||||||||||||
| 主題 | non-AD pathology, tau, THK5351, PET, MMSE, ADAS | |||||||||||||||
| 内容記述 | ||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||
| 内容記述 | Purpose: Our earlier investigation assessed the correlation between regional accumulations of a tau positron emission tomography (PET) tracer (THK5351) and cognitive dysfunction in the Alzheimer's disease (AD) continuum brain. We reported significant correlations between bilateral parietotemporal and left posterior cingulate/precuneus THK5351 accumulations and Mini-Mental State Examination (MMSE)/Alzheimer Disease Assessment Scale-Cognitive Subtest (ADAS) scores. Herein, we explored the relationship between these variables in non-AD pathologic brains. Methods: Thirty-one subjects with non-AD pathologic changes (mean age: 64.6 ± 11.3 yrs) underwent three-dimensional MRI, fluoro-2-deoxyglucose (FDG)-(PET), Pittsburgh compound B (PiB)-amyloid PET, and THK5351-tau PET. All subjects completed the MMSE (mean ± SD score: 27.0 ± 4.1), and 20 subjects (mean age: 63.8 ± 11.9 yrs) also completed the ADAS (9.7 ± 9.3). A voxel-wise statistical analysis using statistical parametric mapping determined the correlations between each subject's FDG and THK imaging results and their MMSE and ADAS scores. Results: The voxel-wise statistical analysis revealed that FDG accumulations in the left temporal cortices were significantly positively correlated with the subjects' MMSE scores and significantly negatively correlated with their ADAS scores. A negative correlation was observed between the subjects' MMSE scores and THK5351 accumulations in the left temporal and medial frontal cortices and the right temporal pole. A positive correlation was observed between the subjects' ADAS scores and THK5351 accumulations in the left temporal cortices and the right anterior temporal lobe. Conclusions: Compared to FDG accumulation, THK5351 accumulations correlated more strongly with neuropsychological test scores in non-AD pathologic brains, likely due to THK5351's affinity for both tau and monoamine oxidase-B. THK5351 measurements may be valuable for clarifying the pathophysiology of non-AD pathologic changes in the brain. |
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| 言語 | en | |||||||||||||||
| 出版者 | ||||||||||||||||
| 出版者 | The Kindai University Medical Association | |||||||||||||||
| 言語 | en | |||||||||||||||
| 資源タイプ | ||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||
| 資源タイプ | departmental bulletin paper | |||||||||||||||
| 出版タイプ | ||||||||||||||||
| 出版タイプ | AM | |||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||||
| ID登録 | ||||||||||||||||
| ID登録 | 10.15100/0002001135 | |||||||||||||||
| ID登録タイプ | JaLC | |||||||||||||||
| 収録物識別子 | ||||||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||||||
| 収録物識別子 | 03866092 | |||||||||||||||
| 収録物識別子 | ||||||||||||||||
| 収録物識別子タイプ | EISSN | |||||||||||||||
| 収録物識別子 | 24327166 | |||||||||||||||
| 書誌情報 |
en : ACTA MEDICA KINDAI UNIVERSITY 巻 49, 号 1, p. 1-6, 発行日 2024-06 |
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