{"created":"2024-04-23T07:56:38.473924+00:00","id":2001116,"links":{},"metadata":{"_buckets":{"deposit":"68658312-fb11-47cb-b93f-77a432cd8157"},"_deposit":{"created_by":42,"id":"2001116","owners":[42],"pid":{"revision_id":0,"type":"depid","value":"2001116"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:02001116","sets":["14:923:1477:1713338090072"]},"author_link":[],"item_2_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1998-06-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"25","bibliographicPageStart":"17","bibliographicVolumeNumber":"23","bibliographic_titles":[{"bibliographic_title":"近畿大学医学雑誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Medical Journal of Kinki University","bibliographic_titleLang":"en"}]}]},"item_2_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Prostaglandin-D-synthase (PGDS)は主に脳周辺の膜組織に存在し，睡眠を調節するPGD_2を合成する酵素として報告されているが，ヒトの尿中においてその存在を確認した．尿中のPGDSは微量で精製して抗体を作ることができなかったので，組換えPGDSを作製し，それを抗原とした抗体を作製し，尿中に存在するPGDSの定量法を確立した．一方，mRNAが脳の他に，心臓・肝臓・腎臓にも存在することを確認した．そして，組換えPGDSをコントロールとしたimmunoblotでPGDSの定量を行い，種々の疾患について尿中PGDSを定量した．クモ膜下出血では増加傾向を示し，脳梗塞では変化が認められなかった．急性心筋梗塞の場合，発病後3日目までは徐々に増加し，4・5病日目と減少傾向を示した．PGDSは組織壊死が生じることで逸脱し，分子量約30,000と低分子量であるため糸球体から，濾過され尿中に排泄されると考えられる．","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"本文データはCiNiiから複製したものである。","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_2_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学医学会","subitem_publisher_language":"ja"}]},"item_2_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03858367","subitem_source_identifier_type":"PISSN"}]},"item_2_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kinki University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"西垣戸, 伸哉","creatorNameLang":"ja"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"AN00063584-19980625-0017.pdf","format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://kindai.repo.nii.ac.jp/record/2001116/files/AN00063584-19980625-0017.pdf"},"version_id":"2f4152b1-d102-4910-a22f-897590d4823c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"prostaglandin-D-synthase (PGDS)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"nested PCR","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"recombinant","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"acute myocardial infarction","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"immunoblot","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"各種病態時におけるヒトprostaglandin-D-synthaseの尿中排泄の検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"各種病態時におけるヒトprostaglandin-D-synthaseの尿中排泄の検討","subitem_title_language":"ja"}]},"item_type_id":"2","owner":"42","path":["1713338090072"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-04-23"},"publish_date":"2024-04-23","publish_status":"0","recid":"2001116","relation_version_is_last":true,"title":["各種病態時におけるヒトprostaglandin-D-synthaseの尿中排泄の検討"],"weko_creator_id":"42","weko_shared_id":-1},"updated":"2024-05-10T02:12:25.521294+00:00"}