{"created":"2024-03-15T00:33:44.812287+00:00","id":2000937,"links":{},"metadata":{"_buckets":{"deposit":"7ae2d44a-a16e-4fc7-bd79-b89547f5fdcb"},"_deposit":{"created_by":42,"id":"2000937","owners":[42],"pid":{"revision_id":0,"type":"depid","value":"2000937"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:02000937","sets":["14:923:1477:1709704794675"]},"author_link":[],"item_2_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1999-06-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"102","bibliographicPageStart":"95","bibliographicVolumeNumber":"24","bibliographic_titles":[{"bibliographic_title":"近畿大学医学雑誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Medical Journal of Kinki University","bibliographic_titleLang":"en"}]}]},"item_2_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"塩基性線維芽細胞増殖因子(basic fibroblast growth factor : bFGF)は，心筋梗塞部の新生血管を増加させ，梗塞サイズを縮小することがイヌの実験で報告されている．イヌは冠副血行路が豊富であるので，これの乏しい家兎で，bFGFが同様の効果をもたらすかを明らかにする．麻酔開胸した家兎の冠動脈支配領域の心筋内に，生理食塩水0.1ml（control群22羽）又はbFGF100μg（bFGF群15羽）を注入後，この冠動脈を結紮し4週間飼育後心臓を摘出した．局所心筋血流量（Qm）と梗塞部，辺縁部の生存心筋，繊維化の程度を顕微鏡にて計測した．Qmは梗塞部では両群間に差はなかったが，辺縁部でcontrol群1.47±0.80ml/min/g，bFGF群3.39±2.68ml/min/gと後者に高い傾向があった．健常部はそれぞれ2.09±0.82，6.06±3.85ml/min/gとbFGF群で有意に増加した．病理組織の顕微鏡写真上で生きた心筋の数を視野に占める%で表すと梗塞部では差がないが辺縁部ではcontrol群35.8±20.3%，bFGF群61.8±8.5%と後者に有意に豊富であった．線維化の程度を線維化のない0から全て線維化した場合を5のスコアで示すと同じく梗塞部では差がないが辺縁部でcontrol群3.3±0.8，bFGF群2.1±0.5と後者で有意に軽かった．以上より家兎の急性冠動脈閉塞ではbFGFにより梗塞部に効果はみられなかったが，辺縁部のQmは増え，同部の心筋壊死は抑制されることが証明された．","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"本文データはCiNiiから複製したものである。","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_2_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学医学会","subitem_publisher_language":"ja"}]},"item_2_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03858367","subitem_source_identifier_type":"PISSN"}]},"item_2_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kinki University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"長谷川, 隆弥","creatorNameLang":"ja"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kinki University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"木村, 彰男","creatorNameLang":"ja"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kinki University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"宮高, 昌","creatorNameLang":"ja"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kinki University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"石川, 欽司","creatorNameLang":"ja"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"AN00063584-19990625-0095.pdf","format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://kindai.repo.nii.ac.jp/record/2000937/files/AN00063584-19990625-0095.pdf"},"version_id":"4ea5e18e-503d-4a19-a7a3-3dd96d5d00ad"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"acute myocardial infarction","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"basic fibroblast growth factor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"myocardial salvage","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"regional myocardial blood flow","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin 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