{"created":"2024-02-01T04:10:21.935935+00:00","id":2000731,"links":{},"metadata":{"_buckets":{"deposit":"77c1b31a-dfc4-4c22-9bc4-ac4acb98a2bb"},"_deposit":{"created_by":42,"id":"2000731","owners":[42],"pid":{"revision_id":0,"type":"depid","value":"2000731"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:02000731","sets":["14:923:1477:1703490120549"]},"author_link":[],"control_number":"2000731","item_2_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2000-12-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"238","bibliographicPageStart":"229","bibliographicVolumeNumber":"25","bibliographic_titles":[{"bibliographic_title":"近畿大学医学雑誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Medical Journal of Kinki University","bibliographic_titleLang":"en"}]}]},"item_2_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"兎の総腸骨動脈をPTCAバルーンにて血管傷害後，組織プラスミノーゲン・アクチベーター(tPA)をDispatchカテーテルを用い傷害した部位に局所注入，その後3日間持続静注により，血管傷害後の内膜過形成がtPAにより防止できるか否かを検討した．32羽の遺伝性高コレステロール血症家兎(KHC)の総腸骨動脈に直径2.5mmのPTCA用バルーンカテーテルを挿入，6気圧60秒拡張を3回施行した．血管傷害後，Dispatchカテーテルを使用してtPA(アルテプラーゼ)を0.6mg/kgを30分間で局所注入，その後耳介静脈よりtPAを0.6mg/kg/24hで3日間持続静注した．32羽の家兎は，I : control群(n=6)，II : Dispatch(+)・tPA(-)群(D(+)・tPA(-))(n=10)，III : Dispatch(+)・tPA30分間局所注入群(D(+)・tPA(30min))(n=8)，IV : Dispatch(+)・tPA30分間局所注入後3日間持続静注群(D(+)・tPA(30min+3days))(n=8)の4群に分け，血管傷害28日後，傷害部の血管の組織学的所見より内膜面積はcontrol群0.60±0.39mm^2に比べてD(+)・tPA(-)群0.21±0.12mm^2，D(+)・tPA(30min)0.19±0.26mm^2，D(+)・tPA(30min+3days)群0.03±0.02mm^2と，有意に小さかった(それぞれp<0.01，p<0.05，p<0.01)．また，D(+)・tPA(-)群に比べてtPA(30min+3days)群で，内膜面積が有意に小さかった(p<0.01)．内膜面積を中膜面積で除した内膜・中膜比はcontrol群0.91±0.22に比べてD(+)・tPA(-)群0.41±0.28，D(+)・tPA(30min)群0.23±0.28，D(+)・tPA(30min+3days)群0.05±0.04と有意に小さかった(それぞれp<0.01)．D(+)・tPA(-)群に比べてtPA(30min+3days)群で内膜・中膜比は有意に小さかった(p<0.05)．DispatchカテーテルによるtPA局所注入後3日間持続静注は，血管傷害後の内膜過形成を防止した．","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"本文データはCiNiiから複製したものである。","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_2_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学医学会","subitem_publisher_language":"ja"}]},"item_2_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03858367","subitem_source_identifier_type":"PISSN"}]},"item_2_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kinki Unversity","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"井上, 嘉一","creatorNameLang":"ja"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kinki Unversity","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"金政, 健","creatorNameLang":"ja"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kinki Unversity","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"石川, 欽司","creatorNameLang":"ja"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"AN00063584-20001225-0229.pdf","format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://kindai.repo.nii.ac.jp/record/2000731/files/AN00063584-20001225-0229.pdf"},"version_id":"7e57888e-81a5-4359-890b-9bc006c20f60"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"tissue plasminogen activator","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Dispatch catheter","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"atherosclerotic rabbit","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"intimal hyperplasia","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"vascular injury","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"restenosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin 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