{"created":"2024-02-01T04:10:12.759524+00:00","id":2000728,"links":{},"metadata":{"_buckets":{"deposit":"8493296a-f974-4a7c-af15-07660419e9fb"},"_deposit":{"created_by":42,"id":"2000728","owners":[42],"pid":{"revision_id":0,"type":"depid","value":"2000728"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:02000728","sets":["14:923:1477:1703490120549"]},"author_link":[],"control_number":"2000728","item_2_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2000-12-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"207","bibliographicPageStart":"199","bibliographicVolumeNumber":"25","bibliographic_titles":[{"bibliographic_title":"近畿大学医学雑誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Medical Journal of Kinki University","bibliographic_titleLang":"en"}]}]},"item_2_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"目的：教室ではこれまでに変形性関節症（Osteoarthritis, OA）および慢性関節リウマチ（Rheumatoid arthritis, RA）に対し，最終的治療として人工関節置換術といった大侵襲の手術を行う前の段階で，関節鏡を用いて大量の生理的食塩水によって関節内を洗浄するという最小侵襲治療により長期にわたる良好な臨床成績が得られることを報告し，その作用機序につき検討を加えてきた．この関節洗浄療法の有効性を炎症の主座である滑膜線維芽細胞のアポトーシス誘導という観点より検討した．ヒト滑膜線維芽細胞を材料とし，灌流負荷を行いアポトーシス検出および，細胞内カルシウムイオン([Ca^<2+>]i)を計測した．OAおよびRAの滑膜線維芽細胞において灌流量及び灌流時間に依存してアポトーシス率の増加を認め，また灌流により[Ca^<2+>]iが一過性に増加し，この細胞内カルシウムをキレートすることによりアポトーシスの発生は抑制された．滑膜線維芽細胞に対する灌流負荷はアポトーシスを惹起し，その情報伝達機構において[Ca^<2+>]iの一過性上昇が関与することが明らかにされ，関節洗浄療法の有効性が実験的に裏付けられた．","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"本文データはCiNiiから複製したものである。","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_2_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学医学会","subitem_publisher_language":"ja"}]},"item_2_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03858367","subitem_source_identifier_type":"PISSN"}]},"item_2_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kinki Unversity","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"岡本, 佳之","creatorNameLang":"ja"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"AN00063584-20001225-0199.pdf","format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://kindai.repo.nii.ac.jp/record/2000728/files/AN00063584-20001225-0199.pdf"},"version_id":"e6fcb602-4fc8-4847-902a-cbbd913ea00e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"synovial fibroblast","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"滑膜線維芽細胞","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"apoptosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"アポトーシス","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"intracellular calucium ion","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞内カルシウムイオン","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"滑膜線維芽細胞に対する灌流負荷によるアポトーシスの誘導と細胞内カルシウムイオンの関与","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"滑膜線維芽細胞に対する灌流負荷によるアポトーシスの誘導と細胞内カルシウムイオンの関与","subitem_title_language":"ja"}]},"item_type_id":"2","owner":"42","path":["1703490120549"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-02-01"},"publish_date":"2024-02-01","publish_status":"0","recid":"2000728","relation_version_is_last":true,"title":["滑膜線維芽細胞に対する灌流負荷によるアポトーシスの誘導と細胞内カルシウムイオンの関与"],"weko_creator_id":"42","weko_shared_id":-1},"updated":"2024-02-16T06:12:45.574218+00:00"}