{"created":"2023-11-15T07:18:30.876365+00:00","id":2000423,"links":{},"metadata":{"_buckets":{"deposit":"86c08778-3e5b-4ffe-8a4c-8b0b09d40e5c"},"_deposit":{"created_by":42,"id":"2000423","owners":[42],"pid":{"revision_id":0,"type":"depid","value":"2000423"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:02000423","sets":["14:2667:1697004343623"]},"author_link":[],"item_1693381679919":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"report","resourceuri":"http://purl.org/coar/resource_type/c_93fc"}]},"item_30001_bibliographic_information17":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicNumberOfPages":"5","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2022)","bibliographic_titleLang":"ja"}]}]},"item_30001_creator2":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"34419","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"伊谷, 善仁","creatorNameLang":"ja"},{"creatorName":"itani, yoshihito","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"70510973","nameIdentifierScheme":"e-Rad"}]}]},"item_30001_description8":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"われわれは, 耳介軟骨を微細加工して軟骨細胞および細胞外基質を含む均一サイズのマイクロ軟骨を作製し, これを細胞供給源として新規軟骨再生技術の確立を試みてきた.この方法は細胞培養を経由しない方法として早期の臨床応用が可能になる利点があげられるが，再生軟骨組織が充分といえなかった．そこで今回，至適コラゲナーゼ表面処理時間および播種マイクロ軟骨の最適化を検討し，生体軟骨組織から臨床応用に必要な軟骨量を低侵襲で効率的に再生誘導しえる事が可能となった.","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"In order to enhance cartilage regeneration, surface modification of the cubic micro-cartilage with the collagenase treatment was tested and its efficacy to tissue engineer ear cartilage was investigated. This method has the advantage of enabling early clinical application as it does not require cell culture, but the regenerated cartilage tissue was not sufficient. In this study, efficacy of collagenase treatment on micro-cartilage to expand cartilage regeneration capacity was examined in special reference to optimum length of collagenase treatment and seeding volume of micro-cartilage blocks for ear cartilage tissue engineering, especially in situations where donor cartilage is limited or unavailable.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"研究分野：軟骨再生","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_30001_file22":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"20K18425seika.pdf","format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://kindai.repo.nii.ac.jp/record/2000423/files/20K18425seika.pdf"},"version_id":"b6a66e4f-b01b-4771-b873-69139485766b"}]},"item_30001_funding_reference15":{"attribute_name":"助成情報","attribute_value_mlt":[{"subitem_award_numbers":{"subitem_award_number":"20K18425","subitem_award_uri":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K18425/"},"subitem_award_titles":[{"subitem_award_title":"コラゲナーゼ表面処理を行った微細加工軟骨の性状が軟骨再生に及ぼす影響","subitem_award_title_language":"ja"},{"subitem_award_title":"Surface modification of the cubic micro-cartilage by collagenase treatment and its efficacy in cartilage regeneration for ear tissue engineering","subitem_award_title_language":"en"}],"subitem_funder_names":[{"subitem_funder_name":"独立行政法人日本学術振興会","subitem_funder_name_language":"ja"},{"subitem_funder_name":"Japan Society for the Promotion of Science","subitem_funder_name_language":"en"}]}]},"item_30001_language10":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_30001_subject7":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"軟骨再生","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"微細加工軟骨","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"コラゲナーゼ処理","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_30001_title0":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"コラゲナーゼ表面処理を行った微細加工軟骨の性状が軟骨再生に及ぼす影響","subitem_title_language":"ja"},{"subitem_title":"Surface modification of the cubic micro-cartilage by collagenase treatment and its efficacy in cartilage regeneration for ear tissue engineering","subitem_title_language":"en"}]},"item_30001_version_type12":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_title":"コラゲナーゼ表面処理を行った微細加工軟骨の性状が軟骨再生に及ぼす影響","item_type_id":"40001","owner":"42","path":["1697004343623"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-11-15"},"publish_date":"2023-11-15","publish_status":"0","recid":"2000423","relation_version_is_last":true,"title":["コラゲナーゼ表面処理を行った微細加工軟骨の性状が軟骨再生に及ぼす影響"],"weko_creator_id":"42","weko_shared_id":-1},"updated":"2024-02-09T05:17:22.641118+00:00"}