{"created":"2023-11-15T07:18:23.720010+00:00","id":2000421,"links":{},"metadata":{"_buckets":{"deposit":"195e0341-32ed-4faf-9746-5ee0a1eb07b2"},"_deposit":{"created_by":42,"id":"2000421","owners":[42],"pid":{"revision_id":0,"type":"depid","value":"2000421"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:02000421","sets":["14:2667:1697004343623"]},"author_link":[],"item_1693381679919":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"report","resourceuri":"http://purl.org/coar/resource_type/c_93fc"}]},"item_30001_bibliographic_information17":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicNumberOfPages":"5","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2022)","bibliographic_titleLang":"ja"}]}]},"item_30001_creator2":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"34419","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"北浦, 淳寛","creatorNameLang":"ja"},{"creatorName":"KITAURA, Atsuhiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"20716485","nameIdentifierScheme":"e-Rad"}]}]},"item_30001_description8":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"糖尿病では免疫の低下が生じ、感染症を発症し、予後を悪化させる。糖尿病による免疫低下のメカニズムについて、長期間高血糖にさらされると産生・蓄積される非常に生理活性が強い糖化最終産物という物質に着目した。糖化最終産物は免疫系にさまざまな影響を与える。そのなかで、免疫系の重要な司令塔であるマクロファージの活性への影響を検討した。結果、糖化最終産物は、グラム陰性桿菌由来のリポポリサッカライド（LPS）という炎症惹起物質のマクロファージへの取り込みを抑制して、細菌への正常な免疫応答を抑制することを明らかとした。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"Diabetes mellitus causes a decrease in immunity, leading to the development of infections and worsening prognosis. To understand the mechanism of immunocompromised immunity caused by diabetes, we focused on a substance called advanced glycation end products (AGEs), which are highly bioactive and are produced and accumulated after prolonged exposure to high blood glucose. AGEs have various effects on the immune system. Among them, we investigated the effects on the activity of macrophages, which are an important command post of the immune system. As a result, we found that AGEs suppress the normal immune response to bacteria by inhibiting the uptake of an inflammation-producing substance called lipopolysaccharide (LPS), which is derived from Gram-negative rods, into macrophages.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"研究分野：麻酔科学","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_30001_file22":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"20K17799seika.pdf","format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://kindai.repo.nii.ac.jp/record/2000421/files/20K17799seika.pdf"},"version_id":"ce538be8-e74b-44f5-a032-e03fb6187fb1"}]},"item_30001_funding_reference15":{"attribute_name":"助成情報","attribute_value_mlt":[{"subitem_award_numbers":{"subitem_award_number":"20K17799","subitem_award_uri":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K17799/"},"subitem_award_titles":[{"subitem_award_title":"糖尿病による免疫機能低下メカニズムの検討","subitem_award_title_language":"ja"},{"subitem_award_title":"Investigation of the mechanism of immune function reduction by diabetes mellitus","subitem_award_title_language":"en"}],"subitem_funder_names":[{"subitem_funder_name":"独立行政法人日本学術振興会","subitem_funder_name_language":"ja"},{"subitem_funder_name":"Japan Society for the Promotion of Science","subitem_funder_name_language":"en"}]}]},"item_30001_language10":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_30001_subject7":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"糖化最終産物","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"糖尿病","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"免疫","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"マクロファージ","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_30001_title0":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"糖尿病による免疫機能低下メカニズムの検討","subitem_title_language":"ja"},{"subitem_title":"Investigation of the mechanism of immune function reduction by diabetes mellitus","subitem_title_language":"en"}]},"item_30001_version_type12":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_title":"糖尿病による免疫機能低下メカニズムの検討","item_type_id":"40001","owner":"42","path":["1697004343623"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-11-15"},"publish_date":"2023-11-15","publish_status":"0","recid":"2000421","relation_version_is_last":true,"title":["糖尿病による免疫機能低下メカニズムの検討"],"weko_creator_id":"42","weko_shared_id":-1},"updated":"2024-10-23T00:48:14.404255+00:00"}