{"created":"2023-11-15T07:18:19.882555+00:00","id":2000420,"links":{},"metadata":{"_buckets":{"deposit":"d0d4697e-b222-4bc4-8853-053c09d64ae4"},"_deposit":{"created_by":42,"id":"2000420","owners":[42],"pid":{"revision_id":0,"type":"depid","value":"2000420"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:02000420","sets":["14:2667:1697004343623"]},"author_link":[],"item_1693381679919":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"report","resourceuri":"http://purl.org/coar/resource_type/c_93fc"}]},"item_30001_bibliographic_information17":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicNumberOfPages":"7","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2022)","bibliographic_titleLang":"ja"}]}]},"item_30001_creator2":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"34419","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"小原, 秀太","creatorNameLang":"ja"},{"creatorName":"Ohara, Shuta","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"20813926","nameIdentifierScheme":"e-Rad"}]}]},"item_30001_description8":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"本研究ではCAPP-SeqとSignateraを用いて術後の予後予測やctDNAの状態と画像検査における再発の関係を評価した。術後すぐの解析（術後中央値9日、範囲2-53日)では5人の患者がctDNA陽性となり全例が再発し、ctDNA陽性は有意に予後不良であった。さらに経過観察中に5人の患者がctDNA陽性となり全例が再発した。また経過観察中に1回でもctDNAが検出されると、有意に予後不良であった。ctDNA陽性の画像検査に対するリードタイム中央値は2.8（0-12.8）カ月であった。ctDNA陰性は予後良好な転帰と関連しており、長期の陰性適中率は83.3％（30/36人）であった。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"In this study, we used CAPP-Seq and Signatera to evaluate the relationship between postoperative prognostic and ctDNA status and recurrence on imaging studies. In a landmark analysis (median 9 days postoperatively, range 2-53 days), 5 patients tested positive for ctDNA and all recurred, with ctDNA positivity associated with a significantly worse prognosis. Five more patients tested positive for ctDNA during follow-up, and all relapsed. The prognosis was significantly worse if ctDNA was detected at least once during follow-up. Overall, the median lead time for ctDNA-positive imaging was 2.8 (0-12.8) months. ctDNA negativity was associated with a favorable outcome, with a long-term negative predictive value of 83.3% (30/36 patients).","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"研究分野：Thoracic surgery","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_30001_file22":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"20K17764seika.pdf","format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://kindai.repo.nii.ac.jp/record/2000420/files/20K17764seika.pdf"},"version_id":"c648e328-d851-40f1-be5d-4cb2bebd42f6"}]},"item_30001_funding_reference15":{"attribute_name":"助成情報","attribute_value_mlt":[{"subitem_award_numbers":{"subitem_award_number":"20K17764","subitem_award_uri":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K17764/"},"subitem_award_titles":[{"subitem_award_title":"次世代シーケンサーによる外科切除症例におけるctDNAの再発予測因子としての意義","subitem_award_title_language":"ja"},{"subitem_award_title":"The Significance of ctDNA as a Predictor of Recurrence in Surgical Resection Cases Using Next-Generation Sequencing","subitem_award_title_language":"en"}],"subitem_funder_names":[{"subitem_funder_name":"独立行政法人日本学術振興会","subitem_funder_name_language":"ja"},{"subitem_funder_name":"Japan Society for the Promotion of Science","subitem_funder_name_language":"en"}]}]},"item_30001_language10":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_30001_subject7":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"circulating tumor DNA","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"liquid biopsy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"reccurence","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"surgery","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"lung cancer","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Signatera","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"CAPP-Seq","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"NSCLC","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_30001_title0":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"次世代シーケンサーによる外科切除症例におけるctDNAの再発予測因子としての意義","subitem_title_language":"ja"},{"subitem_title":"The Significance of ctDNA as a Predictor of Recurrence in Surgical Resection Cases Using Next-Generation Sequencing","subitem_title_language":"en"}]},"item_30001_version_type12":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_title":"次世代シーケンサーによる外科切除症例におけるctDNAの再発予測因子としての意義","item_type_id":"40001","owner":"42","path":["1697004343623"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-11-15"},"publish_date":"2023-11-15","publish_status":"0","recid":"2000420","relation_version_is_last":true,"title":["次世代シーケンサーによる外科切除症例におけるctDNAの再発予測因子としての意義"],"weko_creator_id":"42","weko_shared_id":-1},"updated":"2024-10-23T00:48:14.174050+00:00"}