{"created":"2023-11-15T07:18:11.782991+00:00","id":2000418,"links":{},"metadata":{"_buckets":{"deposit":"6c829dd4-6d24-4729-bff3-98065e1791b5"},"_deposit":{"created_by":42,"id":"2000418","owners":[42],"pid":{"revision_id":0,"type":"depid","value":"2000418"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:02000418","sets":["14:2667:1697004343623"]},"author_link":[],"item_1693378644159":{"attribute_name":"研究分担者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"34419","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"伊木, 雅之","creatorNameLang":"ja"},{"creatorName":"Iki, Masayuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"50184388","nameIdentifierScheme":"e-Rad"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"34401","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"大阪医科薬科大学","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"玉置, 淳子","creatorNameLang":"ja"},{"creatorName":"Tamaki, Junko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"90326356","nameIdentifierScheme":"e-Rad"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"34401","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"大阪医科薬科大学","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"神谷, 訓康","creatorNameLang":"ja"},{"creatorName":"Kamiya, Kuniyasu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"90780073","nameIdentifierScheme":"e-Rad"}]}]},"item_1693381679919":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"report","resourceuri":"http://purl.org/coar/resource_type/c_93fc"}]},"item_30001_bibliographic_information17":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicNumberOfPages":"7","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2022)","bibliographic_titleLang":"ja"}]}]},"item_30001_creator2":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"34419","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"由良, 晶子","creatorNameLang":"ja"},{"creatorName":"Yura, Akiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"80142595","nameIdentifierScheme":"e-Rad"}]}]},"item_30001_description8":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"動物では糖代謝を制御するホルモンとされるオステオカルシン(OC)と低カルボキシル化オステオカルシン(ucOC)がヒトでも糖尿病、メタボリック症候群(MS)、動脈硬化のリスクを上げるかどうかを検討した。JPOSコホート研究参加者女性1316人を対象にBaselineでこれらのアウトカムを発症している者を除き、その後10年間の新規発症を把握した。その結果、OCでは有意な関連は認められず、ucOCでは最低四分位群で糖尿病の発生リスクが高い傾向にあり、MSの発生リスクは有意に高かった。ucOCはヒトにおいても糖代謝を制御している可能性があり、またMSの発生に関与していることが示唆された。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"We investigated whether osteocalcin (OC) and undercarboxylated osteocalcin (ucOC), which are hormones that regulate glucose metabolism in animals, increase the risk of diabetes, metabolic syndrome (MS), and arteriosclerosis in humans. In 1316 women who participated in the JPOS cohort study, excluding those who had these outcomes at baseline, new onsets were captured during the following 10 years. As a result, there was no significant association with OC, and the lowest quartile of ucOC tended to have a higher risk of developing diabetes, and a significantly higher risk of developing MS. It was suggested that ucOC may regulate glucose metabolism and is involved in the development of MS also in humans.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"研究分野：小児のアレルギー関連疾患の大規模疫学研究、骨粗鬆症等の生活習慣病の疫学研究","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_30001_file22":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"20K10516seika.pdf","format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://kindai.repo.nii.ac.jp/record/2000418/files/20K10516seika.pdf"},"version_id":"71e75b15-e970-4104-bf41-dee96bb0d29b"}]},"item_30001_funding_reference15":{"attribute_name":"助成情報","attribute_value_mlt":[{"subitem_award_numbers":{"subitem_award_number":"20K10516","subitem_award_uri":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K10516/"},"subitem_award_titles":[{"subitem_award_title":"オステオカルシン低値は２型糖尿病と動脈硬化のリスクを高めるかー10年追跡研究","subitem_award_title_language":"ja"},{"subitem_award_title":"Is decreased levels of serum osteocalcin associated with increased risk of type 2 diabetes mellitus and atherosclerosis? - A 10-year follow-up study -","subitem_award_title_language":"en"}],"subitem_funder_names":[{"subitem_funder_name":"独立行政法人日本学術振興会","subitem_funder_name_language":"ja"},{"subitem_funder_name":"Japan Society for the Promotion of Science","subitem_funder_name_language":"en"}]}]},"item_30001_language10":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_30001_subject7":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"オステオカルシン","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"低カルボキシル化オステオカルシン","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"２型糖尿病","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"動脈硬化","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_30001_title0":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"オステオカルシン低値は２型糖尿病と動脈硬化のリスクを高めるかー10年追跡研究","subitem_title_language":"ja"},{"subitem_title":"Is decreased levels of serum osteocalcin associated with increased risk of type 2 diabetes mellitus and atherosclerosis? - A 10-year follow-up study -","subitem_title_language":"en"}]},"item_30001_version_type12":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_title":"オステオカルシン低値は２型糖尿病と動脈硬化のリスクを高めるかー10年追跡研究","item_type_id":"40001","owner":"42","path":["1697004343623"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-11-15"},"publish_date":"2023-11-15","publish_status":"0","recid":"2000418","relation_version_is_last":true,"title":["オステオカルシン低値は２型糖尿病と動脈硬化のリスクを高めるかー10年追跡研究"],"weko_creator_id":"42","weko_shared_id":-1},"updated":"2024-10-23T00:48:15.435005+00:00"}