{"created":"2023-11-15T07:18:07.233791+00:00","id":2000417,"links":{},"metadata":{"_buckets":{"deposit":"c78c155a-27c7-4524-b59e-a380c76cc8fe"},"_deposit":{"created_by":42,"id":"2000417","owners":[42],"pid":{"revision_id":0,"type":"depid","value":"2000417"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:02000417","sets":["14:2667:1697004343623"]},"author_link":[],"item_1693378644159":{"attribute_name":"研究分担者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"34419","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"植村, 天受","creatorNameLang":"ja"},{"creatorName":"Uemura, Hiritsugu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"90213397","nameIdentifierScheme":"e-Rad"}]}]},"item_1693381679919":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"report","resourceuri":"http://purl.org/coar/resource_type/c_93fc"}]},"item_30001_bibliographic_information17":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicNumberOfPages":"11","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2022)","bibliographic_titleLang":"ja"}]}]},"item_30001_creator2":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"34419","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"デベラスコ, マルコ","creatorNameLang":"ja"},{"creatorName":"De Velasco, Marco","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"20449838","nameIdentifierScheme":"e-Rad"}]}]},"item_30001_description8":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"前立腺癌の局所の免疫環境について、前立腺癌マウスモデルでアンドロゲン受容体標的治療(ARTA)について検討したところ、新規抗アンドロゲン薬であるアパルタミド薬は腫瘍内に細胞傷害性T細胞の浸潤や活性化が認められた一方、ARの発現を抑制しても免疫抑制的な骨髄由来免疫抑制細胞（MDSC）の発現が上昇し、MDSCは治療の抵抗性に関連していることが分かった。腫瘍微小環境を変化させmonotherapyで効果を引き出すのが難しいPD-L11抗体はSTAT3阻害薬と併用することで腫瘍増殖を抑制することが分かった。これらの成果は米国癌学会(AACR)や日本癌学会(JCA)にて報告した。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"Immune checkpoint blockade has transformed the landscape of cancer therapy but has been ineffective in patients with advanced prostate cancer (PCa). The tumor microenvironment (TME) is a major determinant of antitumor immune response. We have used a transgenic mouse of Pten-null PCa to characterize the TME. Our studies showed that myeloid-derived suppressor cells (MDSCs) were associated with PCa progression. Moreover, androgen deprivation therapy further exacerbated MDSC infiltration and was associated with disease progression in castration-resistant tumors. Targeting MDSCs by neoadjuvant blockade of JAK1/2 plus anti-PD-L1 blockade reinvigorated antitumor T cell immune response resulting in improved therapeutic efficacy. Our studies provide additional insights into the role of MDSCs in PCa. Our system provides a robust tool to further develop strategies targeting the immunosuppressive TME of advanced PCa. Our findings were presented in part at the AACR and JCA annual meetings.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"研究分野：泌尿器腫瘍学","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_30001_file22":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"20K09570seika.pdf","format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://kindai.repo.nii.ac.jp/record/2000417/files/20K09570seika.pdf"},"version_id":"101dadc4-6120-44e1-8d94-0745ea483855"}]},"item_30001_funding_reference15":{"attribute_name":"助成情報","attribute_value_mlt":[{"subitem_award_numbers":{"subitem_award_number":"20K09570","subitem_award_uri":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K09570/"},"subitem_award_titles":[{"subitem_award_title":"前立腺癌における腫瘍微小免疫環境の変化に関する基礎的研究","subitem_award_title_language":"ja"},{"subitem_award_title":"Evaluation of the tumor microimmune environment using mouse models of prostate cancer","subitem_award_title_language":"en"}],"subitem_funder_names":[{"subitem_funder_name":"独立行政法人日本学術振興会","subitem_funder_name_language":"ja"},{"subitem_funder_name":"Japan Society for the Promotion of Science","subitem_funder_name_language":"en"}]}]},"item_30001_language10":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_30001_subject7":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"前立腺癌","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"腫瘍微小環境","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"複合免疫療法","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"遺伝子改変マウスモデル","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_30001_title0":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"前立腺癌における腫瘍微小免疫環境の変化に関する基礎的研究","subitem_title_language":"ja"},{"subitem_title":"Evaluation of the tumor microimmune environment using mouse models of prostate cancer","subitem_title_language":"en"}]},"item_30001_version_type12":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_title":"前立腺癌における腫瘍微小免疫環境の変化に関する基礎的研究","item_type_id":"40001","owner":"42","path":["1697004343623"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-11-15"},"publish_date":"2023-11-15","publish_status":"0","recid":"2000417","relation_version_is_last":true,"title":["前立腺癌における腫瘍微小免疫環境の変化に関する基礎的研究"],"weko_creator_id":"42","weko_shared_id":-1},"updated":"2024-10-23T00:49:12.031837+00:00"}